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MA39983B1 - Dérivés de carboxamide - Google Patents

Dérivés de carboxamide

Info

Publication number
MA39983B1
MA39983B1 MA39983A MA39983A MA39983B1 MA 39983 B1 MA39983 B1 MA 39983B1 MA 39983 A MA39983 A MA 39983A MA 39983 A MA39983 A MA 39983A MA 39983 B1 MA39983 B1 MA 39983B1
Authority
MA
Morocco
Prior art keywords
carboxamide derivatives
present
relates
compounds
manufacture
Prior art date
Application number
MA39983A
Other languages
English (en)
Other versions
MA39983A (fr
Inventor
David Andrew Sandham
Mahbub Ahmed
Anne-Marie D'souza
Nichola Smith
Thomas Josef Troxler
Kamlesh Jagdis Bala
Andrew Brearley
James Dale
David Porter
Jessica Louise Taylor
Roger John Taylor
Joe Wrigglesworth
Robert Alexander Pulz
Lisa Ann Rooney
Duncan Shaw
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50735903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA39983(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA39983A publication Critical patent/MA39983A/fr
Publication of MA39983B1 publication Critical patent/MA39983B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La présente invention concerne un composé de formule (i) ou un sel pharmaceutiquement acceptable de celui-ci; un procédé de fabrication de composés de l'invention et leurs utilisations thérapeutiques. La présente invention concerne, en outre, une combinaison de principes pharmacologiquement actifs et une composition pharmaceutique.
MA39983A 2014-05-14 2015-05-14 Dérivés de carboxamide MA39983B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14168303 2014-05-14
PCT/US2015/030817 WO2015175796A1 (fr) 2014-05-14 2015-05-14 Dérivés de carboxamide

Publications (2)

Publication Number Publication Date
MA39983A MA39983A (fr) 2017-03-22
MA39983B1 true MA39983B1 (fr) 2021-05-31

Family

ID=50735903

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39983A MA39983B1 (fr) 2014-05-14 2015-05-14 Dérivés de carboxamide

Country Status (38)

Country Link
US (6) US9403810B2 (fr)
EP (1) EP3143018B1 (fr)
JP (1) JP6523338B2 (fr)
KR (2) KR102534033B1 (fr)
CN (1) CN106661012B (fr)
AP (1) AP2016009550A0 (fr)
AR (1) AR100440A1 (fr)
AU (1) AU2015259083B2 (fr)
BR (1) BR112016026552B1 (fr)
CA (1) CA2948543C (fr)
CL (1) CL2016002839A1 (fr)
CR (1) CR20160527A (fr)
CU (1) CU24434B1 (fr)
CY (1) CY1124251T1 (fr)
DK (1) DK3143018T3 (fr)
EA (1) EA030938B1 (fr)
ES (1) ES2874882T3 (fr)
HR (1) HRP20210783T1 (fr)
HU (1) HUE054590T2 (fr)
IL (1) IL248785B (fr)
JO (1) JO3610B1 (fr)
LT (1) LT3143018T (fr)
MA (1) MA39983B1 (fr)
MX (1) MX2016014939A (fr)
MY (1) MY186598A (fr)
PE (1) PE20171443A1 (fr)
PH (1) PH12016502246B1 (fr)
PL (1) PL3143018T3 (fr)
PT (1) PT3143018T (fr)
RS (1) RS61874B1 (fr)
SG (1) SG11201609217UA (fr)
SI (1) SI3143018T1 (fr)
SV (1) SV2016005313A (fr)
TN (1) TN2016000489A1 (fr)
TW (2) TWI714528B (fr)
UY (1) UY36124A (fr)
WO (1) WO2015175796A1 (fr)
ZA (1) ZA201607658B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI714528B (zh) 2014-05-14 2021-01-01 瑞士商諾華公司 甲醯胺衍生物
US9403833B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
BR112020008157A2 (pt) * 2017-11-01 2020-10-06 Bristol-Myers Squibb Company compostos espirocíclicos como moduladores do receptor farnesoide x
CN108689976B (zh) * 2018-07-23 2021-12-28 陕西师范大学 5-磺基水杨酸协同二氯二茂钛催化合成4-碘代四氢吡喃衍生物的方法
IL301285A (en) 2020-09-10 2023-05-01 Precirix N V A portion of an antibody against FAP
WO2023203135A1 (fr) 2022-04-22 2023-10-26 Precirix N.V. Anticorps radiomarqué amélioré
AU2023264245A1 (en) 2022-05-02 2024-12-19 Precirix N.V. Pre-targeting

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655009A1 (de) 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
CA2376675A1 (fr) * 1999-06-11 2000-12-21 The Research Foundation Of State University Of New York Antagonistes des voies de signalisation bmp et tgf.beta.
US7354722B1 (en) 1999-06-11 2008-04-08 Signal Pharmaceuticals Modulators of Smurf and BMP/TGFβ signaling pathways
WO2004078163A2 (fr) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a base d'un co-cristal
GB0312368D0 (en) 2003-05-30 2003-07-02 Univ Aston Novel ureido- and amido-pyrazolone derivatives
JP2007506741A (ja) * 2003-09-23 2007-03-22 メルク　エンド　カムパニー　インコーポレーテッド 向代謝性グルタミン酸受容体のピラゾール系調節剤
US7291743B2 (en) 2005-03-29 2007-11-06 Geneblue Corporation Isoxazole derivatives and methods of treating nitric oxide mediated diseases
WO2008121861A2 (fr) 2007-03-28 2008-10-09 Xenon Pharmaceuticals Inc. Composés à base de pyrazole et de pyrrole utiles dans le traitement de troubles du métabolisme du fer
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
ATE524450T1 (de) 2007-08-02 2011-09-15 Organon Nv 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren
KR101218926B1 (ko) 2007-08-22 2013-01-04 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011151361A1 (fr) 2010-06-03 2011-12-08 Glaxo Group Limited Nouveaux composés
CN103380130B (zh) 2011-02-18 2015-06-17 埃科特莱茵药品有限公司 用作为食欲素拮抗剂的新颖的吡唑和咪唑衍生物
TWI714528B (zh) 2014-05-14 2021-01-01 瑞士商諾華公司 甲醯胺衍生物
US20170088546A1 (en) * 2014-05-14 2017-03-30 Novartis Ag Carboxamide inhibitors
US9403833B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
TN2016000503A1 (en) 2014-05-14 2018-04-04 Pfizer Pyrazolopyridines and pyrazolopyrimidines

Also Published As

Publication number Publication date
SV2016005313A (es) 2018-06-12
KR20170003666A (ko) 2017-01-09
TN2016000489A1 (en) 2018-04-04
US11672782B2 (en) 2023-06-13
TW201623296A (zh) 2016-07-01
PL3143018T3 (pl) 2021-08-30
JO3610B1 (ar) 2020-08-27
BR112016026552A8 (pt) 2021-07-06
ZA201607658B (en) 2017-09-27
TWI714528B (zh) 2021-01-01
BR112016026552A2 (pt) 2017-08-15
EP3143018B1 (fr) 2021-03-10
US20190381011A1 (en) 2019-12-19
WO2015175796A1 (fr) 2015-11-19
CU24434B1 (es) 2019-09-04
SG11201609217UA (en) 2016-12-29
US20150329529A1 (en) 2015-11-19
KR20230074827A (ko) 2023-05-31
CU20160166A7 (es) 2017-03-03
US20230301970A1 (en) 2023-09-28
CN106661012A (zh) 2017-05-10
RS61874B1 (sr) 2021-06-30
EP3143018A1 (fr) 2017-03-22
AU2015259083A1 (en) 2016-11-24
HRP20210783T1 (hr) 2021-06-25
CL2016002839A1 (es) 2017-01-27
JP6523338B2 (ja) 2019-05-29
CY1124251T1 (el) 2022-07-22
MX2016014939A (es) 2017-02-28
US9403810B2 (en) 2016-08-02
UY36124A (es) 2016-01-08
PT3143018T (pt) 2021-06-01
CA2948543A1 (fr) 2015-11-19
US10195181B2 (en) 2019-02-05
US20210052554A1 (en) 2021-02-25
PH12016502246A1 (en) 2017-01-09
PH12016502246B1 (en) 2017-01-09
MY186598A (en) 2021-07-29
JP2017515853A (ja) 2017-06-15
LT3143018T (lt) 2021-06-10
CR20160527A (es) 2017-04-28
KR102534033B1 (ko) 2023-05-19
MA39983A (fr) 2017-03-22
EA201692300A1 (ru) 2017-04-28
AP2016009550A0 (en) 2016-11-30
BR112016026552B1 (pt) 2023-02-14
NZ725918A (en) 2023-09-29
AR100440A1 (es) 2016-10-05
AU2015259083B2 (en) 2017-09-14
US20170014388A1 (en) 2017-01-19
HUE054590T2 (hu) 2021-09-28
DK3143018T3 (da) 2021-05-31
IL248785A0 (en) 2017-01-31
US20200268718A1 (en) 2020-08-27
ES2874882T3 (es) 2021-11-05
EA030938B1 (ru) 2018-10-31
CA2948543C (fr) 2022-08-16
TW201946921A (zh) 2019-12-16
SI3143018T1 (sl) 2021-08-31
IL248785B (en) 2020-04-30
CN106661012B (zh) 2019-12-20
PE20171443A1 (es) 2017-09-29

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