MA31684B1 - Composition pharmaceutique contenant un antagoniste des canaux calciques de type dihydropyridine et son procédé de préparation - Google Patents
Composition pharmaceutique contenant un antagoniste des canaux calciques de type dihydropyridine et son procédé de préparationInfo
- Publication number
- MA31684B1 MA31684B1 MA32628A MA32628A MA31684B1 MA 31684 B1 MA31684 B1 MA 31684B1 MA 32628 A MA32628 A MA 32628A MA 32628 A MA32628 A MA 32628A MA 31684 B1 MA31684 B1 MA 31684B1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- calcium channel
- channel antagonist
- pharmaceutical composition
- composition containing
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 229940127291 Calcium channel antagonist Drugs 0.000 title abstract 2
- 239000000480 calcium channel blocker Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 abstract 2
- 229960004294 lercanidipine Drugs 0.000 abstract 2
- 229910002012 Aerosil® Inorganic materials 0.000 abstract 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007909 solid dosage form Substances 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention porte sur la formulation de formes posologiques solides comprenant une quantité thérapeutiquement efficace d'un antagoniste des canaux calciques de type dihydropyridine, tels que la lercanidipine ou un sel de celle-ci, en combinaison avec du dioxyde de silicium colloïdal tel que l'aerosil' pour augmenter la biodisponibilité et améliorer la solubilité. L'invention porte également sur un procédé pour la préparation de ces formes posologiques par granulation par voie humide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2007/006517 WO2009012791A1 (fr) | 2007-07-23 | 2007-07-23 | Composition pharmaceutique contenant un antagoniste des canaux calciques de type dihydropyridine et son procédé de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA31684B1 true MA31684B1 (fr) | 2010-09-01 |
Family
ID=39223083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA32628A MA31684B1 (fr) | 2007-07-23 | 2010-02-17 | Composition pharmaceutique contenant un antagoniste des canaux calciques de type dihydropyridine et son procédé de préparation |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2180883B1 (fr) |
| JP (2) | JP5769963B2 (fr) |
| KR (2) | KR101632079B1 (fr) |
| CN (3) | CN101784260A (fr) |
| AU (2) | AU2007356942B2 (fr) |
| BR (2) | BRPI0721883A2 (fr) |
| CA (2) | CA2691752C (fr) |
| CO (1) | CO6290639A2 (fr) |
| CR (1) | CR11285A (fr) |
| EA (2) | EA021645B1 (fr) |
| EC (1) | ECSP109984A (fr) |
| ES (2) | ES2622495T3 (fr) |
| MA (1) | MA31684B1 (fr) |
| MX (2) | MX2010000856A (fr) |
| MY (1) | MY153857A (fr) |
| NZ (2) | NZ582648A (fr) |
| TN (2) | TN2010000011A1 (fr) |
| UA (2) | UA97161C2 (fr) |
| WO (2) | WO2009012791A1 (fr) |
| ZA (2) | ZA201000586B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008063888A2 (fr) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées |
| BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
| EA021645B1 (ru) * | 2007-07-23 | 2015-08-31 | Фарматен С.А. | Твердая дозированная форма в виде таблетки и способ её приготовления |
| MA33028B1 (fr) * | 2009-04-03 | 2012-02-01 | Plexxikon Inc | Compositions et utilisations associees |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| JP2013510166A (ja) | 2009-11-06 | 2013-03-21 | プレキシコン インコーポレーテッド | キナーゼ調節のための化合物、方法およびその適用 |
| SMT201900112T1 (it) | 2011-02-07 | 2019-02-28 | Plexxikon Inc | Composti e metodi per la modulazione della chinasi, e indicazioni corrispettive |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| GR1008554B (el) * | 2014-06-12 | 2015-09-03 | ΦΑΡΜΑΤΕΝ ΑΝΩΝΥΜΟΣ ΒΙΟΜΗΧΑΝΙΚΗ ΚΑΙ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΙΑΤΡΙΚΩΝ ΚΑΙ ΚΑΛΛΥΝΤΙΚΩΝ ΠΡΟΪΟΝΤΩΝ με δ.τ. ΦΑΡΜΑΤΕΝ, | Φαρμακευτικο σκευασμα περιεχον εναν αντιμυκητιασικο παραγοντα τριaζολης και μεθοδος για την παρασκευη αυτου |
| CN104069500A (zh) * | 2014-06-20 | 2014-10-01 | 湖南天地恒一制药有限公司 | 一种包含乐卡地平的药物组合物 |
| CN105168165B (zh) * | 2015-08-28 | 2018-06-26 | 江苏福邦药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
| WO2018004379A1 (fr) * | 2016-07-01 | 2018-01-04 | Общество С Ограниченной Ответственностью "Гиостин" | Produit sous forme de capsule pour traiter des maladies d'articulations |
| MX2020009756A (es) | 2018-03-22 | 2021-01-29 | Komipharm Int Australia Pty Ltd | Composicion farmaceutica y metodo de fabricacion. |
| CN114533686B (zh) * | 2022-02-15 | 2023-10-20 | 湖南普道医药技术有限公司 | 一种二氢吡啶类药物的口服固体制剂及其制备方法 |
| KR20240040407A (ko) * | 2022-09-21 | 2024-03-28 | 주식회사 종근당 | 사쿠비트릴ㆍ발사르탄 칼슘염을 포함하는 약제학적 조성물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3720757A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| US5209933A (en) * | 1990-01-10 | 1993-05-11 | Syntex (U.S.A.) Inc. | Long acting calcium channel blocker composition |
| GB9025251D0 (en) * | 1990-11-20 | 1991-01-02 | Solomon Montague C | Nifedipine dosage forms |
| BR9903490A (pt) * | 1998-12-15 | 2000-09-26 | Oscar Gold | Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica |
| DE19944803A1 (de) * | 1999-09-20 | 2001-03-29 | Bayer Ag | Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln |
| US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| US20070105912A1 (en) * | 2003-12-01 | 2007-05-10 | Per Holm | Pharmaceutical compositions comprising lercanidipine |
| ZA200605290B (en) * | 2003-12-01 | 2007-10-31 | Lifecycle Pharma As | Pharmaceutical compositions comprising lercanidipine |
| AU2007291506A1 (en) * | 2006-08-30 | 2008-03-06 | Jagotec Ag | Controlled release solid oral dosage formulations comprising nisoldipine |
| EP2101771A2 (fr) * | 2006-12-06 | 2009-09-23 | Torrent Pharmaceuticals Ltd | Formulation stable de lercanidipine |
| EA021645B1 (ru) * | 2007-07-23 | 2015-08-31 | Фарматен С.А. | Твердая дозированная форма в виде таблетки и способ её приготовления |
-
2007
- 2007-07-23 EA EA201070160A patent/EA021645B1/ru not_active IP Right Cessation
- 2007-07-23 EP EP07786262.1A patent/EP2180883B1/fr active Active
- 2007-07-23 CA CA2691752A patent/CA2691752C/fr active Active
- 2007-07-23 WO PCT/EP2007/006517 patent/WO2009012791A1/fr active Application Filing
- 2007-07-23 CN CN200780100025A patent/CN101784260A/zh active Pending
- 2007-07-23 UA UAA201001781A patent/UA97161C2/ru unknown
- 2007-07-23 BR BRPI0721883-4A2A patent/BRPI0721883A2/pt not_active IP Right Cessation
- 2007-07-23 AU AU2007356942A patent/AU2007356942B2/en active Active
- 2007-07-23 NZ NZ582648A patent/NZ582648A/en unknown
- 2007-07-23 ES ES07786262.1T patent/ES2622495T3/es active Active
- 2007-07-23 MX MX2010000856A patent/MX2010000856A/es active IP Right Grant
- 2007-07-23 JP JP2010517273A patent/JP5769963B2/ja not_active Expired - Fee Related
- 2007-07-23 KR KR1020107001425A patent/KR101632079B1/ko active Active
-
2008
- 2008-07-23 CA CA2693233A patent/CA2693233A1/fr not_active Abandoned
- 2008-07-23 MY MYPI2010000318A patent/MY153857A/en unknown
- 2008-07-23 AU AU2008280106A patent/AU2008280106B9/en not_active Ceased
- 2008-07-23 EP EP20080775312 patent/EP2170295B1/fr active Active
- 2008-07-23 CN CN200880100075A patent/CN101801347A/zh active Pending
- 2008-07-23 KR KR1020107002430A patent/KR101512404B1/ko not_active Expired - Fee Related
- 2008-07-23 WO PCT/EP2008/059645 patent/WO2009013306A1/fr active Application Filing
- 2008-07-23 MX MX2010000801A patent/MX2010000801A/es active IP Right Grant
- 2008-07-23 JP JP2010517393A patent/JP2010534220A/ja active Pending
- 2008-07-23 BR BRPI0814666A patent/BRPI0814666A2/pt not_active IP Right Cessation
- 2008-07-23 EA EA201000220A patent/EA019614B1/ru unknown
- 2008-07-23 NZ NZ582690A patent/NZ582690A/en not_active IP Right Cessation
- 2008-07-23 CN CN201410243247.6A patent/CN103976968A/zh active Pending
- 2008-07-23 UA UAA201000447A patent/UA99136C2/ru unknown
- 2008-07-23 ES ES08775312.5T patent/ES2537063T3/es active Active
-
2010
- 2010-01-08 TN TNP2010000011A patent/TN2010000011A1/fr unknown
- 2010-01-13 TN TNP2010000022A patent/TN2010000022A1/fr unknown
- 2010-01-20 CO CO10005281A patent/CO6290639A2/es not_active Application Discontinuation
- 2010-01-26 ZA ZA2010/00586A patent/ZA201000586B/en unknown
- 2010-02-17 MA MA32628A patent/MA31684B1/fr unknown
- 2010-02-18 ZA ZA2010/01176A patent/ZA201001176B/en unknown
- 2010-02-19 CR CR11285A patent/CR11285A/es unknown
- 2010-02-23 EC EC2010009984A patent/ECSP109984A/es unknown
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