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MA30062B1 - Vaccin - Google Patents

Vaccin

Info

Publication number
MA30062B1
MA30062B1 MA31046A MA31046A MA30062B1 MA 30062 B1 MA30062 B1 MA 30062B1 MA 31046 A MA31046 A MA 31046A MA 31046 A MA31046 A MA 31046A MA 30062 B1 MA30062 B1 MA 30062B1
Authority
MA
Morocco
Prior art keywords
conjugated
composition
saccharide
relates
capsular
Prior art date
Application number
MA31046A
Other languages
English (en)
Inventor
Ralph Leon Biemans
Nathalie Marie-Josephe Garcon
Philippe Vincent Hermand
Jan Poolman
Mechelen Marcelle Paulette Van
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39133667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30062(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0526232A external-priority patent/GB0526232D0/en
Priority claimed from GB0607087A external-priority patent/GB0607087D0/en
Priority claimed from GBGB0607088.2A external-priority patent/GB0607088D0/en
Priority claimed from GB0609902A external-priority patent/GB0609902D0/en
Priority claimed from GB0620337A external-priority patent/GB0620337D0/en
Priority claimed from GBGB0620336.8A external-priority patent/GB0620336D0/en
Priority claimed from GB0620815A external-priority patent/GB0620815D0/en
Priority claimed from GB0620816A external-priority patent/GB0620816D0/en
Priority claimed from PCT/GB2006/004634 external-priority patent/WO2007068907A2/fr
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of MA30062B1 publication Critical patent/MA30062B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
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    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des vaccins pneumococciques à base de conjugués de saccharides capsulaires. Plus particulièrement, elle concerne une composition immunogène de Streptococcus pneumoniae comprenant plusieurs saccharides capsulaires conjugués issus de différents sérotypes de S. pneumoniae conjugués à au moins 2 protéines-supports différentes, la composition comprenant un saccharide capsulaire de sérotype 19F conjugué à une anatoxine diphtérique (DT) ou CRM 197, 19F étant éventuellement le seul saccharide dans la composition conjugué à une anatoxine diphtérique (DT) ou CRM197.
MA31046A 2005-12-22 2008-06-18 Vaccin MA30062B1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0526232A GB0526232D0 (en) 2005-12-22 2005-12-22 Vaccine
GB0607087A GB0607087D0 (en) 2006-04-07 2006-04-07 Vaccine
GBGB0607088.2A GB0607088D0 (en) 2006-04-07 2006-04-07 Vaccine
GB0609902A GB0609902D0 (en) 2006-05-18 2006-05-18 Novel composition
GB0620337A GB0620337D0 (en) 2006-10-12 2006-10-12 Vaccine
GBGB0620336.8A GB0620336D0 (en) 2006-10-12 2006-10-12 Vaccine
GB0620815A GB0620815D0 (en) 2006-10-19 2006-10-19 Vaccine
GB0620816A GB0620816D0 (en) 2006-10-19 2006-10-19 vaccine
PCT/GB2006/004634 WO2007068907A2 (fr) 2005-12-13 2006-12-12 Nouvelle composition

Publications (1)

Publication Number Publication Date
MA30062B1 true MA30062B1 (fr) 2008-12-01

Family

ID=39133667

Family Applications (3)

Application Number Title Priority Date Filing Date
MA31046A MA30062B1 (fr) 2005-12-22 2008-06-18 Vaccin
MA31049A MA30065B1 (fr) 2005-12-22 2008-06-18 Vaccin
MA31050A MA30066B1 (fr) 2005-12-22 2008-06-18 Vaccin

Family Applications After (2)

Application Number Title Priority Date Filing Date
MA31049A MA30065B1 (fr) 2005-12-22 2008-06-18 Vaccin
MA31050A MA30066B1 (fr) 2005-12-22 2008-06-18 Vaccin

Country Status (36)

Country Link
US (10) US20090017059A1 (fr)
EP (10) EP1962899B1 (fr)
JP (7) JP5579387B2 (fr)
KR (5) KR101365001B1 (fr)
CN (6) CN101374548B (fr)
AR (3) AR058706A1 (fr)
AT (1) ATE520415T1 (fr)
AU (4) AU2006327040B2 (fr)
BR (3) BRPI0620460B8 (fr)
CA (5) CA2816182C (fr)
CL (1) CL2013002106A1 (fr)
CR (2) CR10119A (fr)
CY (5) CY1112677T1 (fr)
DK (5) DK1962899T3 (fr)
EA (3) EA014649B1 (fr)
ES (4) ES2539795T3 (fr)
HR (4) HRP20110685T1 (fr)
HU (3) HUE033081T2 (fr)
IL (5) IL191911A (fr)
JO (1) JO2813B1 (fr)
LT (3) LT1973564T (fr)
MA (3) MA30062B1 (fr)
MX (2) MX354843B (fr)
MY (4) MY148141A (fr)
NO (4) NO345368B1 (fr)
NZ (4) NZ569076A (fr)
PE (2) PE20071305A1 (fr)
PH (1) PH12014502544A1 (fr)
PL (5) PL1968631T3 (fr)
PT (5) PT3017827T (fr)
SG (1) SG168517A1 (fr)
SI (5) SI2384765T1 (fr)
TR (1) TR201900418T4 (fr)
TW (4) TWI465248B (fr)
UA (2) UA96583C2 (fr)
WO (3) WO2007071710A2 (fr)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2279748A1 (fr) * 2000-06-29 2011-02-02 SmithKline Beecham Biologicals S.A. Composition vaccinale multivalente
EP1333858B8 (fr) 2000-11-07 2006-06-14 Immunovaccine Technologies Inc. Vaccins a reponse immunitaire accrue et leurs procedes de preparation
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2878579C (fr) 2005-04-08 2018-01-23 Wyeth Composition conjuguee polysaccharide-proteine pneumococcique polyvalente
AU2006263964B2 (en) 2005-06-27 2010-05-20 Pfizer Ireland Pharmaceuticals Immunogenic composition
SI2384765T1 (sl) * 2005-12-22 2017-03-31 Glaxosmithkline Biologicals S.A. Streptococcus pneumoniae vakcina
WO2008022298A2 (fr) * 2006-08-17 2008-02-21 The Uab Research Foundation Polypeptides pcpa immunogènes et utilisations associées
EP2155244B1 (fr) * 2007-04-23 2017-03-22 Serum Institute of India Private Limited Polysaccharides antigéniques et procédé pour leur préparation
EA201490303A1 (ru) 2007-05-02 2014-05-30 Глаксосмитклайн Байолоджикалс С.А. Вакцина
PT2167121E (pt) * 2007-06-26 2015-12-02 Glaxosmithkline Biolog Sa Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
JP5731198B2 (ja) 2007-09-27 2015-06-10 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． インビボでのポリヌクレオチドの送達のための連続疎水相を含む担体におけるリポソームの使用
WO2009050586A1 (fr) 2007-10-19 2009-04-23 Novartis Ag Formulations de vaccin méningococcique
EP2252326A4 (fr) * 2008-02-01 2012-08-29 Newcastle Innovation Ltd Compositions de vaccin
ES2553113T3 (es) * 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vacuna
BRPI0910884A2 (pt) * 2008-04-16 2015-10-06 Glaxonsmithkline Biolog S A composição imunogênica, método para tratar ou prevenir infecção ou doença estafilocócicas, e, uso de uma composição imunogênica.
EP2293815A4 (fr) * 2008-05-22 2013-04-03 Childrens Medical Center Conjugué immunogène synergique protéine de fusion-polysaccharide
CN102056622B (zh) 2008-06-05 2016-04-06 免疫疫苗技术有限公司 包含脂质体、抗原、多核苷酸和含疏水物质的连续相的载体的组合物
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PL3017827T3 (pl) 2019-04-30
JP5615323B2 (ja) 2014-10-29
CA2634885C (fr) 2016-04-19
PL1973564T3 (pl) 2017-04-28
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PL1968631T3 (pl) 2015-08-31
IL192084A (en) 2013-11-28
IL191911A0 (en) 2008-12-29
EP3130348A1 (fr) 2017-02-15
PT3017827T (pt) 2019-01-28
ES2614938T3 (es) 2017-06-02
AU2006327041B2 (en) 2010-08-26
EP2402025A2 (fr) 2012-01-04
EP2382986A2 (fr) 2011-11-02
EP3470080A1 (fr) 2019-04-17
NO20082646L (no) 2008-09-16
ES2539795T3 (es) 2015-07-06
PT1973564T (pt) 2017-01-24
TWI415622B (zh) 2013-11-21
CN101378778B (zh) 2013-02-06
CR10122A (fr) 2008-08-21
EP2384765B1 (fr) 2016-11-23
US20090017072A1 (en) 2009-01-15
CY1121376T1 (el) 2020-05-29
EP3017827A1 (fr) 2016-05-11
TWI487534B (zh) 2015-06-11
CA2816182A1 (fr) 2007-06-28
NO20082718L (no) 2008-09-16
ATE520415T1 (de) 2011-09-15
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TW200738258A (en) 2007-10-16
SI2384765T1 (sl) 2017-03-31
CN101374548B (zh) 2013-05-01
JP5579387B2 (ja) 2014-08-27
BRPI0620163B1 (pt) 2019-08-13
BRPI0620460B8 (pt) 2021-05-25
US20190262447A1 (en) 2019-08-29
EA200801374A1 (ru) 2008-12-30
US20160243219A1 (en) 2016-08-25
WO2007071707A2 (fr) 2007-06-28
SG168517A1 (en) 2011-02-28
AU2010241281B2 (en) 2012-12-06
AU2006327040B2 (en) 2010-08-19
KR20080081060A (ko) 2008-09-05

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