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MA30911B1 - Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine - Google Patents

Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine

Info

Publication number
MA30911B1
MA30911B1 MA31906A MA31906A MA30911B1 MA 30911 B1 MA30911 B1 MA 30911B1 MA 31906 A MA31906 A MA 31906A MA 31906 A MA31906 A MA 31906A MA 30911 B1 MA30911 B1 MA 30911B1
Authority
MA
Morocco
Prior art keywords
sulfonamide derivatives
novel sulfonamide
antagonists
bradykinine
derivatives
Prior art date
Application number
MA31906A
Other languages
English (en)
Inventor
Eva Bozo
Gyula Beke
Janos Eles
Sandor Farkas
Katalin Hornok
Gyoergy Keserue
Eva Schmidt
Eva Szentirmay
Istvan Vago
Monika Vastag
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA30911B1 publication Critical patent/MA30911B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX DÉRIVÉS SULFONAMIDES DE FORMULE (I), DANS LAQUELLE R1 À R5 ET Z SONT TELS QUE DÉFINIS DANS LES REVENDICATIONS, AINSI QUE DES ANTIPODES OPTIQUES OU DES RACÉMATES ET/OU DES SELS ET/OU DES HYDRATES ET/OU DES SOLVATES DE CES DÉRIVÉS, QUI SONT DES ANTAGONISTES SÉLECTIFS DE LA BRADYKININE B1. L'INVENTION CONCERNE ÉGALEMENT DES PROCÉDÉS DE PRÉPARATION DE CES COMPOSÉS, DES COMPOSITIONS PHARMACOLOGIQUES LES CONTENANT ET LEUR UTILISATION DANS LE TRAITEMENT OU LA PRÉVENTION D'ÉTATS DOULOUREUX ET INFLAMMATOIRES.
MA31906A 2006-10-27 2009-05-21 Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine MA30911B1 (fr)

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CN101528681A (zh) 2009-09-09
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US20100075978A1 (en) 2010-03-25
AU2007310588A1 (en) 2008-05-02
HU0600810D0 (en) 2006-12-28
WO2008050168A1 (fr) 2008-05-02
EP2074083A1 (fr) 2009-07-01
GEP20125437B (en) 2012-03-26
BRPI0718495A2 (pt) 2013-12-03
EP2074083B1 (fr) 2013-06-19
HUP0600810A3 (en) 2008-09-29
CA2667285C (fr) 2012-09-25
WO2008050168A8 (fr) 2009-04-09
EA018046B1 (ru) 2013-05-30
JP2010507644A (ja) 2010-03-11
IL198345A0 (en) 2010-02-17
CU20090070A7 (es) 2011-05-27
EA200900606A1 (ru) 2009-08-28
CU23840B1 (es) 2012-10-15
KR20090076927A (ko) 2009-07-13
MX2009004527A (es) 2009-07-02
MY148076A (en) 2013-02-28
NZ575762A (en) 2011-12-22
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