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MA27117A1 - (imidazol-1-yl-methyl)-pyridazine en tant qu'antagoniste du recepteur nmda - Google Patents

(imidazol-1-yl-methyl)-pyridazine en tant qu'antagoniste du recepteur nmda

Info

Publication number
MA27117A1
MA27117A1 MA27943A MA27943A MA27117A1 MA 27117 A1 MA27117 A1 MA 27117A1 MA 27943 A MA27943 A MA 27943A MA 27943 A MA27943 A MA 27943A MA 27117 A1 MA27117 A1 MA 27117A1
Authority
MA
Morocco
Prior art keywords
disease
neurodegeneration
compounds
pyridazine
imidazol
Prior art date
Application number
MA27943A
Other languages
English (en)
Inventor
Bernd Buettelmann
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Georg Jaeschke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27117A1 publication Critical patent/MA27117A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(IMIDAZOL-1-YL-MÉTHYL)-PYRIDAZINE EN TANT QU'ANTAGONISTE DU RÉCEPTEUR POUR LE NMDA La présente invention concerne des composés de formule (I) dans laquelle A est un groupe cyclique non substitué; et R est l'hydrogène ou un alkyle inférieur; et des sels pharmaceutiquement acceptables de ceux-ci. Il s'est avéré que les composés de formule IA et IB sont de bons antagonistes spécifiques du sous-type de récepteurs pour le NMDA NR-2B. Des indications thérapeutiques possibles pour ces composés comprennent des formes aigues de neurodégénérescence provoquées, par exemple, par l'apoplexie et des traumatismes cérébraux, et des formes chroniques de neurodégénérescence telles que la maladie d'Alzheimer, la maladie de Parkinson, la maladie de Huntington, la SLA (sclérose latérale amyotrophique) et la neurodégénérescence associée à des infections bactériennes ou virales et, en outre, la dépression et la douleur chronique et aigue.
MA27943A 2002-05-16 2004-11-12 (imidazol-1-yl-methyl)-pyridazine en tant qu'antagoniste du recepteur nmda MA27117A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02010217 2002-05-16

Publications (1)

Publication Number Publication Date
MA27117A1 true MA27117A1 (fr) 2004-12-20

Family

ID=29433072

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27943A MA27117A1 (fr) 2002-05-16 2004-11-12 (imidazol-1-yl-methyl)-pyridazine en tant qu'antagoniste du recepteur nmda

Country Status (31)

Country Link
US (1) US7005432B2 (fr)
EP (1) EP1506190B1 (fr)
JP (1) JP4267569B2 (fr)
KR (1) KR100632868B1 (fr)
CN (1) CN1312151C (fr)
AR (1) AR040010A1 (fr)
AT (1) ATE329912T1 (fr)
AU (1) AU2003242542B2 (fr)
BR (1) BR0311177A (fr)
CA (1) CA2485926C (fr)
CL (1) CL2004001251A1 (fr)
CY (1) CY1105159T1 (fr)
DE (1) DE60306152T2 (fr)
DK (1) DK1506190T3 (fr)
ES (1) ES2265581T3 (fr)
HK (1) HK1080845A1 (fr)
HR (1) HRP20041060B1 (fr)
IL (1) IL164922A (fr)
MA (1) MA27117A1 (fr)
ME (1) MEP76708A (fr)
MX (1) MXPA04011253A (fr)
NO (1) NO329605B1 (fr)
NZ (1) NZ536310A (fr)
PL (1) PL211340B1 (fr)
PT (1) PT1506190E (fr)
RS (1) RS51200B (fr)
RU (1) RU2317294C2 (fr)
SI (1) SI1506190T1 (fr)
TN (1) TNSN04224A1 (fr)
WO (1) WO2003097637A1 (fr)
ZA (1) ZA200408789B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
CN100579579C (zh) * 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
KR101289923B1 (ko) * 2005-05-03 2013-07-25 메르크 파텐트 게엠베하 유기 전계발광 장치 및 그에 사용되는 붕산 및 보린산유도체
US20090054392A1 (en) * 2007-08-20 2009-02-26 Wyeth Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
JP5315710B2 (ja) * 2008-02-07 2013-10-16 セントラル硝子株式会社 １−ブロモ−３−フルオロ−５−ジフルオロメチルベンゼンの製造方法
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
KR20100135847A (ko) * 2008-03-27 2010-12-27 에보텍 뉴로사이언시즈 게엠베하 Ｎｍｄａ ｎｒ２ｂ―서브타입 선택적 길항제를 사용한 질병 치료 방법
PE20110991A1 (es) 2009-02-05 2012-02-06 Takeda Pharmaceutical Compuestos de fenil-piridazinona-pirazol-fenilo como inhibidores de pde
EP2602255B1 (fr) * 2010-08-04 2017-04-26 Takeda Pharmaceutical Company Limited Composé à cycle hétérocyclique fusionné
WO2012019106A2 (fr) * 2010-08-06 2012-02-09 Board Of Regents Of The University Of Nebraska Modulateurs positifs et négatifs des récepteurs nmda
WO2013160728A1 (fr) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Composés à double ciblage pour le traitement de la maladie d'alzheimer
US9981950B2 (en) * 2014-08-15 2018-05-29 Janssen Pharmaceuticals, Inc. Triazoles as NR2B receptor inhibitors
BR112018016329A2 (pt) 2016-02-10 2018-12-18 Janssen Pharmaceutica Nv 1,2,3-triazóis substituídos como moduladores de nmda seletivos para nr2b
CO2018008470A2 (es) 2016-02-18 2018-09-20 Syngenta Participations Ag Derivados de pirazol pesticídicamente activos
WO2017158151A1 (fr) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Dérivés de pyrimidone et leur utilisation dans le traitement, le soulagement ou la prévention d'une maladie virale
WO2017158147A1 (fr) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Dérivés de pyrimidone et leur utilisation pour le traitement, la prévention ou l'atténuation des symptômes d'une maladie virale
TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
US11274107B2 (en) 2016-12-22 2022-03-15 Cadent Therapeutics, Inc. NMDA receptor modulators and uses thereof
WO2019193516A2 (fr) 2018-04-04 2019-10-10 Janssen Pharmaceutica Nv Pyridine et pyrimidines substituées et leur utilisation en tant que modulateurs du récepteur glun2b
RS64359B1 (sr) 2018-08-03 2023-08-31 Novartis Ag Heteroaromatični modulatori nmda receptora i njihove upotrebe
BR112021025132A2 (pt) 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Carbamatos de piridina e seu uso como moduladores do receptor glun2b
MX2021015506A (es) 2019-06-14 2022-02-10 Janssen Pharmaceutica Nv Amidas de pirazolo-piridina sustituidas y su uso como moduladores del receptor glun2b.
US11459336B2 (en) 2019-06-14 2022-10-04 Janssen Pharmaceutica Nv Pyrazine carbamates and their use as GluN2B receptor modulators
CR20210615A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b
WO2020249802A1 (fr) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyrazolo-pyrazines substituées et leur utilisation en tant que modulateurs du récepteur de glun2b
KR20220020917A (ko) 2019-06-14 2022-02-21 얀센 파마슈티카 엔.브이. 치환된 피라졸로[4,3-b]피리딘 및 GLUN2B 수용체 조절제로서의 이들의 용도
CN114478210A (zh) * 2022-02-26 2022-05-13 江苏壹药新材料有限公司 一种7-氯萘-2-甲醛的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3248917B2 (ja) * 1996-03-08 2002-01-21 エフ．ホフマン−ラ ロシュ アーゲー ４―フェニル―３，６―ジヒドロ―２ｈ―ピリジル誘導体のｎｍｄａレセプターサブタイプブロッカーとしての用途
CA2220649C (fr) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag Derives de 4-hydroxy-piperidine
US6015824A (en) * 1998-02-10 2000-01-18 Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
DE60007697T2 (de) * 1999-07-21 2004-12-09 F. Hoffmann-La Roche Ag Triazolderivate
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
TR200402442T4 (tr) * 2000-04-20 2004-12-21 F.Hoffmann-La Roche Ag Pirolidin ve piperidin türevleri ve bunların nörodejeneratif bozuklukların tedavisinde kullanımları
US6432985B2 (en) * 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
AU2001296994A1 (en) 2000-10-06 2002-04-15 Regents Of The University Of California Nmda receptor channel blocker with neuroprotective activity
CA2381630A1 (fr) 2001-04-23 2002-10-23 Leonard Theodore Meltzer Methode de prevention de la dyskinesie
DE10120159A1 (de) 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives

Also Published As

Publication number Publication date
ATE329912T1 (de) 2006-07-15
CN1312151C (zh) 2007-04-25
RU2004136979A (ru) 2005-07-10
NO20044666L (no) 2004-12-15
ZA200408789B (en) 2005-12-28
EP1506190A1 (fr) 2005-02-16
IL164922A0 (en) 2005-12-18
CY1105159T1 (el) 2009-11-04
KR100632868B1 (ko) 2006-10-13
KR20040106558A (ko) 2004-12-17
JP4267569B2 (ja) 2009-05-27
EP1506190B1 (fr) 2006-06-14
SI1506190T1 (sl) 2006-10-31
CL2004001251A1 (es) 2005-04-22
US7005432B2 (en) 2006-02-28
HK1080845A1 (en) 2006-05-04
BR0311177A (pt) 2005-03-15
MEP76708A (en) 2011-12-20
DE60306152T2 (de) 2007-04-26
TNSN04224A1 (fr) 2007-03-12
WO2003097637A1 (fr) 2003-11-27
CA2485926C (fr) 2009-11-24
PL211340B1 (pl) 2012-05-31
ES2265581T3 (es) 2007-02-16
US20030229096A1 (en) 2003-12-11
DE60306152D1 (de) 2006-07-27
CA2485926A1 (fr) 2003-11-27
RS98504A (en) 2006-12-15
JP2005532326A (ja) 2005-10-27
DK1506190T3 (da) 2006-10-16
AU2003242542B2 (en) 2008-10-16
MXPA04011253A (es) 2005-01-25
RU2317294C2 (ru) 2008-02-20
HRP20041060A2 (en) 2005-06-30
HRP20041060B1 (en) 2012-11-30
IL164922A (en) 2012-01-31
NZ536310A (en) 2007-08-31
NO329605B1 (no) 2010-11-22
AU2003242542A1 (en) 2003-12-02
AR040010A1 (es) 2005-03-09
CN1653062A (zh) 2005-08-10
PT1506190E (pt) 2006-11-30
RS51200B (sr) 2010-12-31
PL374224A1 (en) 2005-10-03

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