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MA26659A1 - Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. - Google Patents

Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.

Info

Publication number
MA26659A1
MA26659A1 MA25646A MA25646A MA26659A1 MA 26659 A1 MA26659 A1 MA 26659A1 MA 25646 A MA25646 A MA 25646A MA 25646 A MA25646 A MA 25646A MA 26659 A1 MA26659 A1 MA 26659A1
Authority
MA
Morocco
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
benzimidazole derivatives
novel benzimidazole
Prior art date
Application number
MA25646A
Other languages
English (en)
Inventor
Ito Fumitaka
Kondo Hiroshi
Noguchi Hirohide
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26659A1 publication Critical patent/MA26659A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA25646A 1998-08-06 1999-06-25 Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. MA26659A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06

Publications (1)

Publication Number Publication Date
MA26659A1 true MA26659A1 (fr) 2004-12-20

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25646A MA26659A1 (fr) 1998-08-06 1999-06-25 Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.

Country Status (44)

Country Link
US (1) US6172067B1 (fr)
EP (1) EP1102762B1 (fr)
JP (1) JP3367945B2 (fr)
CN (1) CN1317968A (fr)
AP (1) AP2001002063A0 (fr)
AR (1) AR018686A1 (fr)
AT (1) ATE227716T1 (fr)
AU (1) AU749166B2 (fr)
BG (1) BG105301A (fr)
BR (1) BR9912778A (fr)
CA (1) CA2339621C (fr)
CZ (1) CZ2001397A3 (fr)
DE (1) DE69903953T2 (fr)
DK (1) DK1102762T3 (fr)
EA (1) EA200100104A1 (fr)
EE (1) EE200100075A (fr)
ES (1) ES2185357T3 (fr)
GE (1) GEP20033000B (fr)
GT (1) GT199900125A (fr)
HK (1) HK1040188A1 (fr)
HN (1) HN1999000105A (fr)
HR (1) HRP20010089B1 (fr)
HU (1) HUP0103567A3 (fr)
ID (1) ID27212A (fr)
IL (1) IL141029A0 (fr)
IS (1) IS5812A (fr)
MA (1) MA26659A1 (fr)
NO (1) NO20010603L (fr)
NZ (1) NZ509299A (fr)
OA (1) OA11590A (fr)
PA (1) PA8477701A1 (fr)
PE (1) PE20000868A1 (fr)
PL (1) PL346211A1 (fr)
PT (1) PT1102762E (fr)
SI (1) SI1102762T1 (fr)
SK (1) SK1602001A3 (fr)
SV (1) SV1999000099A (fr)
TN (1) TNSN99142A1 (fr)
TR (1) TR200100403T2 (fr)
TW (1) TW513424B (fr)
UY (1) UY25659A1 (fr)
WO (1) WO2000008013A2 (fr)
YU (1) YU8201A (fr)
ZA (1) ZA200100900B (fr)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
DE60023100T2 (de) * 2000-01-05 2006-07-06 Pfizer Inc. Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
AU2403802A (en) * 2000-11-15 2002-05-27 Banyu Pharma Co Ltd Benzimidazole derivatives
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
DE60229736D1 (de) 2001-04-18 2008-12-18 Euro Celtique Sa Spiroinden- und spiroindan-verbindungen
CN100352816C (zh) * 2001-04-18 2007-12-05 欧罗赛铁克股份有限公司 伤害感受肽类似物
CA2444634C (fr) 2001-04-18 2011-06-07 R. Richard Goehring Composes de spiropyrazole
KR100722207B1 (ko) * 2001-04-18 2007-05-29 유로-셀티크 소시에떼 아노뉨 노시셉틴 유사체
PT1385518E (pt) * 2001-04-18 2008-10-07 Euro Celtique Sa Compostos de benzimidazolona
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) * 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
WO2003049736A1 (fr) * 2001-12-11 2003-06-19 Sepracor, Inc. Piperidines 4-substitues, et methodes d'utilisation
AU2003220886A1 (en) 2002-03-29 2003-10-13 Mitsubishi Pharma Corporation Remedy for sleep disturbance
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
AR045939A1 (es) 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
WO2005060947A2 (fr) * 2003-12-19 2005-07-07 Sri International Ligands agonistes et antagonistes du recepteur de la nociceptine
CA2583326A1 (fr) * 2004-10-08 2006-04-13 Takeda Pharmaceutical Company Limited Agent de regulation du fonctionnement d'un recepteur
EP1838306B1 (fr) 2005-01-11 2010-11-17 NeuroSearch A/S Nouveaux derives de 2-amino benzimidazole et leur utilisation en tant que modulateurs des canaux a potassium actives par le calcium a faible conductance
US20090239880A1 (en) * 2006-07-03 2009-09-24 Ulrik Svane Sorensen Combinations of monoamine reuptake inhibitors and potassium channel activators
JP5462633B2 (ja) 2007-01-16 2014-04-02 パーデュー、ファーマ、リミテッド、パートナーシップ 複素環置換ピペリジン化合物とその使用
EP2433936A1 (fr) * 2007-08-31 2012-03-28 Purdue Pharma LP Composés de pipéridine de type quinoxaline substituée et leurs utilisations
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
MX2011000872A (es) 2008-07-21 2011-07-29 Purdue Pharma Lp Compuestos de piperidina puenteada tipo quinoxalina sustituida y los usos de los mismos.
JP5795635B2 (ja) 2010-08-05 2015-10-14 アムジェン インコーポレイテッド 未分化リンパ腫キナーゼを阻害するベンゾイミダゾール化合物およびアザベンゾイミダゾール化合物
MX346043B (es) 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
AU2013216828B2 (en) 2012-02-09 2017-01-12 Novus International Inc. Functionalized polymer compositions
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
ES2703051T3 (es) 2012-07-12 2019-03-06 Novus Int Inc Composiciones de matriz y de capa para la protección de agentes bioactivos
US9085561B2 (en) * 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102594A2 (fr) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Composés de pipéridine de type benzimidazole substitué et leurs utilisations
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
MX2016012097A (es) * 2014-03-20 2017-04-27 Capella Therapeutics Inc Derivados de bencimidazol como inhibidores de tirosina cinasa erbb para el tratamiento del cáncer.
AU2016353076A1 (en) 2015-11-12 2018-05-10 Novus International Inc. Sulfur-containing compounds as solvents
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

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US3318900A (en) * 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS5297978A (en) * 1976-06-02 1977-08-17 Yoshitomi Pharmaceut Ind Ltd Preparation of alicyclic derivatives
US5821219A (en) 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
CA2229202C (fr) 1995-08-15 2008-05-20 Universite Libre De Bruxells Methodes pour l'identification d'antagonistes ou d'agonistes du recepteur orl-1 humain
US5866346A (en) 1995-09-27 1999-02-02 Indiana Unversity Foundation Methods of using dynorphins as ligands for XOR1 receptor
WO1997040035A1 (fr) * 1996-04-19 1997-10-30 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles presentant une activite neurotrophique
EP0813065A3 (fr) 1996-06-13 1998-07-22 F. Hoffmann-La Roche Ag Modulation de la fonction d'un récepteur LC-132(analogue à opioide)
EP0829481A1 (fr) * 1996-09-16 1998-03-18 Pfizer Inc. Dérivés de l'acide morphinane hydroxamique
US5718912A (en) * 1996-10-28 1998-02-17 Merck & Co., Inc. Muscarine agonists
CA2291094C (fr) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. Derive de 2-0xoimidazole
AU8334298A (en) 1997-07-15 1999-02-10 Novo Nordisk A/S Nociceptin analogues
US5929035A (en) 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
CZ2001397A3 (cs) 2002-05-15
HN1999000105A (es) 2000-11-11
NO20010603D0 (no) 2001-02-05
AP2001002063A0 (en) 2001-03-31
NZ509299A (en) 2003-05-30
CN1317968A (zh) 2001-10-17
TW513424B (en) 2002-12-11
GT199900125A (es) 2001-01-27
ZA200100900B (en) 2002-08-28
PE20000868A1 (es) 2000-08-31
YU8201A (sh) 2003-07-07
PL346211A1 (en) 2002-01-28
OA11590A (en) 2004-08-18
ES2185357T3 (es) 2003-04-16
DK1102762T3 (da) 2002-12-16
GEP20033000B (en) 2003-06-25
US6172067B1 (en) 2001-01-09
DE69903953D1 (de) 2002-12-19
JP2002522431A (ja) 2002-07-23
SI1102762T1 (en) 2003-04-30
EP1102762A2 (fr) 2001-05-30
IS5812A (is) 2001-01-16
JP3367945B2 (ja) 2003-01-20
WO2000008013A2 (fr) 2000-02-17
HK1040188A1 (zh) 2002-05-31
EP1102762B1 (fr) 2002-11-13
IL141029A0 (en) 2002-02-10
TR200100403T2 (tr) 2001-07-23
BR9912778A (pt) 2001-09-25
WO2000008013A3 (fr) 2000-03-23
HUP0103567A3 (en) 2003-01-28
AU4385999A (en) 2000-02-28
TNSN99142A1 (fr) 2005-11-10
BG105301A (en) 2001-12-29
SV1999000099A (es) 2000-09-05
EE200100075A (et) 2002-06-17
ATE227716T1 (de) 2002-11-15
UY25659A1 (es) 2000-02-23
ID27212A (id) 2001-03-08
AU749166B2 (en) 2002-06-20
CA2339621A1 (fr) 2000-02-17
PT1102762E (pt) 2003-02-28
EA200100104A1 (ru) 2001-08-27
DE69903953T2 (de) 2003-03-27
HUP0103567A2 (hu) 2002-02-28
SK1602001A3 (en) 2002-09-10
HRP20010089B1 (en) 2003-04-30
CA2339621C (fr) 2005-04-05
PA8477701A1 (es) 2000-09-29
HRP20010089A2 (en) 2002-02-28
NO20010603L (no) 2001-04-05
AR018686A1 (es) 2001-11-28

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