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Hutzler et al., 2009 - Google Patents

Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (±)-suprofen: a comparison of kinetics and probe substrate selection

Hutzler et al., 2009

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Document ID
3890343340477720610
Author
Hutzler J
Balogh L
Zientek M
Kumar V
Tracy T
Publication year
Publication venue
Drug metabolism and disposition

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In vitro experiments were conducted to compare k inact, KI and inactivation efficiency (k inact/KI) of cytochrome P450 (P450) 2C9 by tienilic acid and (±)-suprofen using (S)- flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates. Although the inactivation of …
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