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Haining et al., 1999 - Google Patents

Enzymatic determinants of the substrate specificity of CYP2C9: role of B '− C loop residues in providing the π-stacking anchor site for warfarin binding

Haining et al., 1999

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Document ID
10679973434626977052
Author
Haining R
Jones J
Henne K
Fisher M
Koop D
Trager W
Rettie A
Publication year
Publication venue
Biochemistry

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Previous modeling efforts have suggested that coumarin ligand binding to CYP2C9 is dictated by electrostatic and π-stacking interactions with complementary amino acids of the protein. In this study, analysis of a combined CoMFA-homology model for the enzyme …
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    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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