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Lee et al., 2009 - Google Patents

New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sites

Lee et al., 2009

View PDF @Free from Publisher
Document ID
14814655211709583885
Author
Lee I
Ajay S
Yook J
Kim H
Hong S
Kim N
Dhanasekaran S
Chinnaiyan A
Athey B
Publication year
Publication venue
Genome research

External Links

Snippet

MicroRNAs (miRNAs) are known to post-transcriptionally regulate target mRNAs through the 3′-UTR, which interacts mainly with the 5′-end of miRNA in animals. Here we identify many endogenous motifs within human 5′-UTRs specific to the 3′-ends of miRNAs. The …
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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