Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

MicroRNA in control of gene expression: an overview of nuclear functions

C Catalanotto, C Cogoni, G Zardo - International journal of molecular …, 2016 - mdpi.com
The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a
sequence specific manner has had a massive impact on biology. Recent improvements in …

MicroRNAs in body fluids—the mix of hormones and biomarkers

MA Cortez, C Bueso-Ramos, J Ferdin… - Nature reviews Clinical …, 2011 - nature.com
Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

M Pu, J Chen, Z Tao, L Miao, X Qi, Y Wang… - Cellular and Molecular …, 2019 - Springer
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a
majority of biological processes via regulating target gene expression. The post …

A brief review on the mechanisms of miRNA regulation

Y Cai, X Yu, S Hu, J Yu - Genomics, Proteomics and …, 2009 - academic.oup.com
MicroRNAs (miRNAs) are a class of short, endogenously-initiated non-coding RNAs that
post-transcriptionally control gene expression via either translational repression or mRNA …

Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation

A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …

miRNA targets: from prediction tools to experimental validation

G Riolo, S Cantara, C Marzocchi, C Ricci - Methods and protocols, 2020 - mdpi.com
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals
and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs …

Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

LW Barrett, S Fletcher, SD Wilton - Cellular and molecular life sciences, 2012 - Springer
There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Treating cancer with microRNA replacement therapy: A literature review

N Hosseinahli, M Aghapour, PHG Duijf… - Journal of cellular …, 2018 - Wiley Online Library
microRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression post‐
transcriptionally by interfering with the translation of one or more target mRNAs. The unique …