Allen et al., 2014 - Google Patents
Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levelsAllen et al., 2014
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- 11277511218030795479
- Author
- Allen M
- Kachadoorian M
- Quicksall Z
- Zou F
- Chai H
- Younkin C
- Crook J
- Pankratz V
- Carrasquillo M
- Krishnan S
- Nguyen T
- Ma L
- Malphrus K
- Lincoln S
- Bisceglio G
- Kolbert C
- Jen J
- Mukherjee S
- Kauwe J
- Crane P
- Haines J
- Mayeux R
- Pericak-Vance M
- Farrer L
- Schellenberg G
- Alzheimer’s Disease Genetics Consortium (ADGC)
- Parisi J
- Petersen R
- Graff-Radford N
- Dickson D
- Younkin S
- Ertekin-Taner N
- Publication year
- Publication venue
- Alzheimer's research & therapy
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Snippet
Introduction MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer's disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although insufficient …
- 210000004556 Brain 0 title abstract description 52
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Hybridisation probes
- C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
- G06—COMPUTING; CALCULATING; COUNTING
- G06F—ELECTRICAL DIGITAL DATA PROCESSING
- G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
- G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
- G06F19/18—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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