CaJacob et al., 1986 - Google Patents
Mechanism-based in vivo inactivation of lauric acid hydroxylasesCaJacob et al., 1986
- Document ID
- 7322903526761945682
- Author
- CaJacob C
- Ortiz de Montellano P
- Publication year
- Publication venue
- Biochemistry
External Links
Snippet
Revised Manuscript Received April 9, 1986 abstract: The hepatic cytochrome P-450 isozymes that catalyze- and (-l)-hydroxylation of lauric acid are specifically inactivated in vitro but not in vivo by 10-undecynoic acid. The lack of in vivo activity may result from rapid …
- 102000005297 Cytochrome P-450 CYP4A 0 title abstract description 12
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Nikolaou et al. | Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2 | |
Zhu et al. | The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice | |
Ryle et al. | Stopped-flow kinetic analysis of Escherichia coli taurine/α-ketoglutarate dioxygenase: interactions with α-ketoglutarate, taurine, and oxygen | |
O’Donnell et al. | Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease | |
Smith et al. | The enzymology of prostaglandin endoperoxide H synthases-1 and-2 | |
Gonasun et al. | Benzene metabolism in mouse liver microsomes | |
Ngui et al. | In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4′-and 10-hydroxywarfarin | |
CaJacob et al. | Mechanism-based in vivo inactivation of lauric acid hydroxylases | |
Ashour et al. | Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases | |
Chan et al. | Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene | |
Wang et al. | Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones | |
Ortiz-Maldonado et al. | Use of free energy relationships to probe the individual steps of hydroxylation of p-hydroxybenzoate hydroxylase: studies with a series of 8-substituted flavins | |
Gan et al. | 1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo [a] pyrene hydroxylase activity in liver microsomes | |
Sjakste et al. | Endothelium-and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate | |
Reiter et al. | Chemically-induced glutathione depletion and lipid peroxidation | |
Vandevoorde et al. | Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase | |
Upmacis et al. | Oxidative alterations of cyclooxygenase during atherogenesis | |
Chaiyen et al. | Unusual mechanism of oxygen atom transfer and product rearrangement in the catalytic reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | |
Hutzler et al. | Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (±)-suprofen: a comparison of kinetics and probe substrate selection | |
MacKerell jr et al. | Human mitochondrial aldehyde dehydrogenase inhibition by diethyldithiocarbamic acid methanethiol mixed disulfide: a derivative of disulfiram | |
Lake et al. | Structure-activity relationships for induction of peroxisomal enzyme activities by phthalate monoesters in primary rat hepatocyte cultures | |
Freeman et al. | Microsomal metabolism of acetonitrile to cyanide: Effects of acetone and other compounds | |
Parke et al. | The 1990 Pharmaceutical Manufacturers Association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals | |
Friedman et al. | 5-Oxoprolinal: transition-state aldehyde inhibitor of pyroglutamyl-peptide hydrolase | |
Kolachana et al. | Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis |