From the medical diagnostic perspective (and for many other applications), you can understand why it might be very convenient to be able to perform some kind of optical imaging of the interior of what you'd ordinarily consider opaque objects. Even when a wavelength range is chosen so that absorption is minimized, photons can scatter many times as they make their way through dense tissue like a breast. We now have serious computing power and extremely sensitive photodetectors, which has led to the development of imaging techniques to perform imaging through media that absorb and diffuse photons. Here is a review of this topic from 2005, and another more recent one (pdf link here). There are many cool approaches that can be combined, including using pulsed lasers to do time-of-flight measurements (review here), and using "structured illumination" (review here).
Sure, point that laser at my head. (Adapted from Figure 1 of this paper.) |
I mention all of this to set the stage for this fun preprint, titled "Photon transport through the entire adult human head". Sure, you think your head is opaque, but it only attenuates photon fluxes by a factor of around \(10^{18}\). With 1 Watt of incident power at 800 nm wavelength spread out over a 25 mm diameter circle and pulsed 80 million times a second, time-resolved single-photon detectors like photomultiplier tubes can readily detect the many-times-scattered photons that straggle their way out of your head around 2 nanoseconds later. (The distribution of arrival times contains a bunch of information. Note that the speed of light in free space is around 30 cm/ns; even accounting for the index of refraction of tissue, those photons have bounced around a lot before getting through.) The point of this is that those photons have passed through parts of the brain that are usually considered inaccessible. This shows that one could credibly use spectroscopic methods to get information out of there, like blood oxygen levels.