Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2gene.[5]
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[5]
CACNA2D2 containing channels are blocked by amiodarone.[6]
Honorio S, Gordon K, MacCartney D, et al. (2002). "Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene". Mol. Cell. Probes. 15 (6): 391–3. doi:10.1006/mcpr.2001.0382. PMID11851383.
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID11085536.
Hobom M, Dai S, Marais E, et al. (2000). "Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit". Eur. J. Neurosci. 12 (4): 1217–26. doi:10.1046/j.1460-9568.2000.01009.x. PMID10762351. S2CID82569498.
