CACNA1I

CACNA1I
Identifiers
Aliases	CACNA1I, Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDs	OMIM: 608230; MGI: 2178051; HomoloGene: 69331; GeneCards: CACNA1I; OMA:CACNA1I - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,689,735 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,282,480 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; primary visual cortex; ; middle temporal gyrus; ; Brodmann area 46; ; entorhinal cortex; ; Region I of hippocampus proper; ; postcentral gyrus; ; superior frontal gyrus; ; glutes; ; right frontal lobe;
	Top expressed in
	striatum of neuraxis; ; olfactory bulb; ; superior frontal gyrus; ; visual cortex; ; primary visual cortex; ; cerebellum; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; hippocampus proper; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium channel activity; low voltage-gated calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated sodium channel activity;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; membrane; plasma membrane;
Biological process	flagellated sperm motility; membrane depolarization during action potential; calcium ion import; regulation of ion transmembrane transport; ion transport; positive regulation of calcium ion-dependent exocytosis; sleep; calcium ion transmembrane transport; transmembrane transport; calcium ion transport; signal transduction; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8911
	239556
	ENSG00000100346
	ENSMUSG00000022416
	Q9P0X4
	n/a
	NM_001003406; NM_021096
	NM_001044308
	NP_001003406; NP_066919
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Ca_v3.3 is a protein which in humans is encoded by the CACNA1I gene.^[5]^[6]^[7]

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
^ Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.
^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

External links

CACNA1i+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNA1I genome location and CACNA1I gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".

[pmid10454147-6] Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.

[pmid16382099-7] Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

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Function

See also

References

External links