Multiscale Study on Hemodynamics in Patient-Specific Thoracic Aortic Coarctation

In this challenge, we intended to mimic the patient's cardiovascular system by using 0D-3D connected multiscale model. The purpose of the multiscale analysis is to find out the appropriate boundary conditions of the innominate artery IA, left common carotid artery LCA and left subclavian artery LSA in the local 3D computational fluid dynamics simulation. Firstly, a lumped parameter modelLPM of the patient's circulatory system was established which could mimic both the rest and stress conditions by adjusting parameters like elastance function of the heart and the peripheral resistance, since that administering is oprenaline leads to the patient's heart beat rate and peripheral resistance changes. Secondly, the values of parameters in the LPM were slightly revised to match the following conditions: 1. provided pressure and flow rate curves, 2. provided blood distribution ratio of the AcsAo, IA, LCA and LSA. Finally, we got the outlet conditions of the IA, LCA and LSA, and then connecting the 0D model and the 3D model at each time step. As the results, we got the streamlines, pressure drop through the coarctation, pressure gradient, and some other parameters by coupled multiscale simuation.