Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions
Fig 12
(A) shows the outgoing (axonal) projections of an excitatory neuron in the peri-LPZ. (B) shows the outgoing (axonal) projections of an inhibitory neuron in the LPZ C. From left to right: t = 2000 s, t = 4000 s, and t = 18,000 s. As per our suggested growth rules for pre-synaptic elements, excitatory neurons produce new pre-synaptic elements and sprout axonal projections when they experience extra activity, while inhibitory neurons form new pre-synaptic elements and grow axons when they are deprived of activity. As a consequence and in line with experimental data, following deafferentation of the LPZ, excitatory neurons in the peri-LPZ sprout new outgoing projections that help transfer excitatory activity to neurons in the LPZ. Also in accordance with experimental work, inhibitory neurons inside the LPZ form new outgoing connections that transmit inhibition to neurons outside the LPZ.