07/03/2025
research article
To unravel detailed metabolic activities in the human colonic epithelium, this study focuses on the generation of the first cell-type specific genome-scale metabolic model (GEM) of human colonic epithelial cells, named iColonEpithelium.
Image credit: Jiang et al
Current Issue June 2025
07/01/2025
research article
This paper presents a workflow composed of Free and Open Source Software (FOSS) that enables research labs to self-host tools for communication and storage with relative ease. Through this Lab Operations (LabOps) workflow, academics can enhance collaborative efficiency while strengthening data security and sovereignty over the long term.
Image credit: Roman-Palacios & Garcia-Verduo
07/30/2025
research article
Understanding the structural basis of protein-protein interactions between pathogens and hosts is critical for elucidating pathogenic mechanisms and guiding treatment or vaccine development. Despite 21,064 experimentally supported human-pathogen interactions in the HPIDB, only 52 have resolved structures in the PDB, representing just 0.2%.
Image credit: Saluri, Landreh, Bryant
06/17/2025
research article
Using a simplified biophysical network model, the authors investigate the potential role of cholinergic modulation, acting via the muscarinic receptors, on network dynamics and memory consolidation.
Image credit: Rehina Sultanova
06/10/2025
Perspective
This article discusses the creation and organization of a national core facility for bioimage analysis, based on a distributed team. F-BIAS federates bioimage analysts across France and relies on them to deliver services to the researchers of this territory.
Image credit: Ambroset et al
01/23/2025
Education
However, effective translation of AI and deep learning methods requires computational researchers to have at least a basic understanding of histopathology. This work aims to bridge that gap by introducing essential histopathology concepts to support AI developers in their research.
Image credit: Mandal et al
01/24/2025
Research Article
This study explores how behavioral patterns vary across contexts and alliances.
Image credit: Hans Veth
01/23/2025
Research Article
This study proposes a data-driven approach to validate the applicability of mathematical models.
01/10/2025
Education
In many cases, the goal of conducting new experiments in protein design is optimizing for a property or improving the machine learning model. Many standard methods for these two tasks require good estimates of the uncertainty in the model’s predictions.
Image credit: NCI
12/30/2024
Education
This paper provides a step-by-step tutorial to train 4 different ML models to predict drug resistance for E. coli isolates and to evaluate their performance.
Image credit: Wikipedia
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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