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Integrating Signals from the T-Cell Receptor and the Interleukin-2 Receptor

Figure 5

Revised model of IL-2R signaling.

The interpretation is similar to Figure 1. The revised connections after the IL-2 experiments in human T blasts are taken into account as indicated in Figs. 24 with new connections (including validated potential interactions) shown as thick black lines and removed connections as thick grey lines. The changes are also listed in Table S3. Note, that some connections based on below-quality-standard data remain that are not highlighted (Table S2).

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1002121.g005