Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses
Figure 8
Simulation of decreased mTOR sensitivity.
In this version of the AR model mTOR sensitivity to lower ATP levels is decreased by 20% and lifespan is compared to the simulation in Figure 6. An initial decline in mTOR becomes reversed by increasing ROS levels, enhanced by mTOR mediated activation of biosynthesis and mitochondrial activities. This is an example of “unsuccessful aging”, demonstrating the critical role of mTOR in the regulation of the aging process.