Identifying Tightly Regulated and Variably Expressed Networks by Differential Rank Conservation (DIRAC)
Figure 4
Deregulation of networks in disease.
For each dataset, networks were selected according to the greatest absolute difference in rank conservation between the two phenotypes. Using this subset of networks, the rank conservation index values in the less malignant phenotype (y-axis) were plotted against indices in the more malignant phenotype (x-axis). Higher rank conservation in the less or more malignant phenotypes is indicated by points above or below the diagonal line, respectively. Panel labels (A–K) correspond to datasets listed in Table 2.