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TLR Agonists as Adjuvants for Cancer Vaccines

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Regulation of Inflammatory Signaling in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1024))

Abstract

Toll-like receptors (TLRs) are one of the best characterised families of pattern recognition receptors (PRRs) and play a critical role in the host defence to infection. Accumulating evidence indicates that TLRs also participate in maintaining tissue homeostasis by controlling inflammation and tissue repair, as well as promoting antitumour effects via activation and modulation of adaptive immune responses. TLR agonists have successfully been exploited to ameliorate the efficacy of various cancer therapies. In this chapter, we will discuss the rationales of using TLR agonists as adjuvants to cancer treatments and summarise the recent findings of preclinical and clinical studies of TLR agonist-based cancer therapies.

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Authors and Affiliations

  1. Department of General Surgery, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China

    Ji-Kun Li & Liang Yu

  2. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, 3168, VIC, Australia

    Jesse J. Balic, Liang Yu & Brendan Jenkins

  3. Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, 3800, VIC, Australia

    Jesse J. Balic, Liang Yu & Brendan Jenkins

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  1. Ji-Kun Li
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  2. Jesse J. Balic
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  3. Liang Yu
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  4. Brendan Jenkins
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Correspondence to Liang Yu .

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Editors and Affiliations

  1. Faculty of Medical Laboratory Science, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Dakang Xu

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Li, JK., Balic, J.J., Yu, L., Jenkins, B. (2017). TLR Agonists as Adjuvants for Cancer Vaccines. In: Xu, D. (eds) Regulation of Inflammatory Signaling in Health and Disease. Advances in Experimental Medicine and Biology, vol 1024. Springer, Singapore. https://doi.org/10.1007/978-981-10-5987-2_9

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