Through comprehensive genomic and immune analyses, mechanisms of lung cancer resistance after treatment with EGFR inhibition and vaccine therapy were investigated. This case report, together with data from the longitudinal lung cancer study TRACERx, highlight the importance of understanding when targeted variants are acquired during the cancer’s evolutionary history.

Cancer vaccines must induce immune cells, called CD8⁺ T cells, that can recognize cancer cells over the long term. In pancreatic cancer, a common and deadly cancer, RNA vaccines that encode neoantigens — mutant proteins found only in cancer cells — induce substantial numbers of long-lived CD8⁺ T cells with preserved function, and their presence correlates with better clinical outcomes at a three-year follow-up.

Cellular organelles called mitochondria contain DNA and can fuse together or split apart. It emerges that excess fusion is averted by stress-activated regulators, preventing the potentially harmful release of mitochondrial DNA.

Implementing a performance-rating system with a two-point scale instead of a five-point scale could be an easy way to temper racial prejudices and tangibly improve income equality for workers from under-represented groups.