CXCL3

CXCL3
Identifikatori
Aliasi	CXCL3
Vanjski ID-jevi	OMIM: 139111 MGI: 1340094 HomoloGene: 117695 GeneCards: CXCL3
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	74,038,807 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	91,053,797 bp
Ontologija gena
Molekularna funkcija	• chemokine activity; • cytokine activity; • CXCR chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• chemokine-mediated signaling pathway; • Hemotaksija; • response to lipopolysaccharide; • inflammatory response; • regulation of cell population proliferation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • neutrophil chemotaxis; • positive regulation of neutrophil chemotaxis; • defense response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Izvori:Amigo / QuickGO
Ortolozi
	2921
	20310
	ENSG00000163734
	ENSMUSG00000058427
	P19876
	P10889
	NM_002090
	NM_009140
	NP_002081
	NP_033166
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski ligand 3 (C-X-C motiv) jest mali citokin koji je kod ljudi kodiran genom CXCL3 sa hromosoma 4. Pripada porodici CXC hemokina koja je poznata i kao onkogen GRO3 (GRO3), GRO proteinska gama (GROg) i makrofagni upalni protein-2-beta (MIP2b) .

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 107 aminokiselina, а molekulska težina 11.342 Da.^[5].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAHATLSAAP	SNPRLLRVAL	LLLLLVAASR	RAAGASVVTE	LRCQCLQTLQ
GIHLKNIQSV	NVRSPGPHCA	QTEVIATLKN	GKKACLNPAS	PMVQKIIEKI
LNKGSTN

Funkcija

CXCL3 kontrolira hemotaksijsku migraciju i adheziju monocita i posreduje svoje efekte na ciljnu ćeliju, interakcijom sa ćelijskom površinom hemokinskog receptora zvanog CXCR2.^[6]^[7] Nedavno je pokazano da Cxcl3 autonomno regulira migraciju prekursora neurona granulastih ćelija malog mozga prema njegovim unutrašnjim slojevima, tokom morfogeneze cerebelluma.^[8] Štaviše, ako je ekspresija Cxcl3 smanjena u prekursorima neurona cerebelumske granule, to značajno povećava učestalost meduloblastoma, tumora malog mozga. U stvari, smanjena ekspresija Cxcl3 tjera prekursore neurona malog mozga da ostanu na površini, gdje se jako razmnožavaju pod stimulacijom zvučnog ježa, postajući meta transformirajućih povreda. Zanimljivo je da tretman putem CXCL3 u potpunosti sprečava rast lezija meduloblastoma na mišjem modelu meduloblastoma tipa Shh.^[9] Stoga je CXCL3 meta za terapiju meduloblastoma. Cxcl3 je direktno reguliran transkripcijski, pomoću BTG2^[8]

Na hromosomu 4, gen za CXCL3 nalazi se u grupi drugih CXC hemokina.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163734 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058427 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt, P19876" (jezik: engleski). Pristupljeno 23. 10. 2021.
^ Smith DF, Galkina E, Ley K, Huo Y (novembar 2005). "GRO family chemokines are specialized for monocyte arrest from flow". Am. J. Physiol. Heart Circ. Physiol. 289 (5): H1976–84. doi:10.1152/ajpheart.00153.2005. PMID 15937099.
^ Ahuja SK, Murphy PM (august 1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
^ ^a ^b Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F (oktobar 2012). "Tis21 knock-out enhances the frequency of medulloblastoma in patched1 heterozygous mice by inhibiting the cxcl3-dependent migration of cerebellar neurons". The Journal of Neuroscience. 32 (44): 15547–15564. doi:10.1523/JNEUROSCI.0412-12.2012. PMC 6621585. PMID 23115191.
^ Ceccarelli M, Micheli L & Tirone F (2016). "Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3". Frontiers in Pharmacology. 7: 484. doi:10.3389/fphar.2016.00484. PMC 5159413. PMID 28018222.
^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

Vanjski linkovi

Lokacija ljudskog genoma CXCL3 i stranica sa detaljima o genu CXCL3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163734 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058427 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt, P19876" (jezik: engleski). Pristupljeno 23. 10. 2021.

[pmid15937099-6] Smith DF, Galkina E, Ley K, Huo Y (novembar 2005). "GRO family chemokines are specialized for monocyte arrest from flow". Am. J. Physiol. Heart Circ. Physiol. 289 (5): H1976–84. doi:10.1152/ajpheart.00153.2005. PMID 15937099.

[pmid8702798-7] Ahuja SK, Murphy PM (august 1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.

[pmid23115191-8] Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F (oktobar 2012). "Tis21 knock-out enhances the frequency of medulloblastoma in patched1 heterozygous mice by inhibiting the cxcl3-dependent migration of cerebellar neurons". The Journal of Neuroscience. 32 (44): 15547–15564. doi:10.1523/JNEUROSCI.0412-12.2012. PMC 6621585. PMID 23115191.

[9] Ceccarelli M, Micheli L & Tirone F (2016). "Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3". Frontiers in Pharmacology. 7: 484. doi:10.3389/fphar.2016.00484. PMC 5159413. PMID 28018222.

[pmid10343098-10] O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

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