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Established in 2016, the Human Cell Atlas (HCA) consortium set out to create a comprehensive biological map of cells within the human body. Now progressing into a data integration phase, the HCA is working towards assembling the first draft of this atlas, focusing on 18 biological network atlases. Towards this milestone, they have compiled a collection of papers that highlight essential achievemen
AlphaFold3 can predict the structures of proteins as they interact with DNA.Credit: Werel et al./American Society for Microbiology, Mol*, RCSB PDB AlphaFold3 is open at last. Six months after Google DeepMind controversially withheld code from a paper describing the protein-structure prediction model1, scientists can now download the software code and use the artificial intelligence (AI) tool for n
Despite many seeing the result as a step backwards, the research community should engage with the new administration with courage, tenacity, strength and unity. Moving on: Donald Trump’s re-election poses challenges for science.Credit: Loren Elliott/Getty When Donald Trump was first elected to the US presidency in 2016, Nature advised scientists to constructively engage with Trump. We said that th
After graduating from the medical and biological illustration programme at Johns Hopkins University in Baltimore, Maryland, Shiz Aoki fulfilled a long-held dream: she launched her own company. Founded in 2010 in Toronto, Canada, Anatomize Studios works with large clients — pharmaceutical companies, magazines and medical professionals with niche needs and capacious budgets. Yet Aoki would often als
The prehistory of the Japanese Archipelago is represented by the “Jomon period”, a Neolithic period. The name “Jomon”, meaning “rope pattern”, reflects the distinctive feature of the Jomon culture, characterized by pottery with a unique pattern created using rope [1]. Although there are various opinions about the duration of the Jomon period, archeological evidence widely supports that it started
EDITORIAL 08 October 2024 Nobel prizes are globally unrepresentative — the nomination process must be opened up The geography of science is changing. As a result, a big push is needed to broaden the pool of scientists eligible to nominate their peers for Nobel prizes. The annual Lindau conferences (pictured) introduce early-career scientists to Nobel prizewinners.Credit: Christian Flemming/Lindau
Researchers have mapped nearly 140,000 neurons in the fruit-fly brain. This version shows the 50 largest. Credit: Tyler Sloan and Amy Sterling for FlyWire, Princeton University (ref. 1) A fruit fly might not be the smartest organism, but scientists can still learn a lot from its brain. Researchers are hoping to do that now that they have a new map — the most complete for any organism so far — of t
A recent study has examined adult height in relation to cancer risk in a cohort of 23 million Korean adults. Taller stature was associated with higher risk of every cancer studied, except for oesophageal cancer. This association contributes to our understanding of cancer and may help aid in cancer risk prediction. The association between taller stature and higher risk of many cancers is remarkably
Increasing numbers of companies have pledged to reach net zero by 20501 to support climate mitigation efforts under the Paris Agreement2. To reach this goal with minimal changes to the underlying business, many companies are using or plan to use carbon offsets (also known as carbon credits)3. Offsets can be procured at low cost and are abundant on the voluntary carbon market (VCM). The appeal of o
Depression is a heterogeneous and episodic neuropsychiatric syndrome associated with synapse loss5,6 and connectivity alterations in frontostriatal networks7,8,9 and a leading cause of disability worldwide10. The neurobiological mechanisms that give rise to specific depressive symptom domains or to changes in mood over time are not well understood, especially at the neural systems level. So far, m
As digital devices and the Internet become integral parts of daily life, concerns about their potential negative impact on human well-being, especially that of prolonged screen time, have become more pronounced. Video games, at the forefront of this debate, increasingly encounter public scepticism1. Controversial health policy decisions, such as the latest discussions by the World Health Organizat
Methane (CH4) is the most important anthropogenically enhanced greenhouse gas in the atmosphere after CO2, contributing an extra 26% of anthropogenic greenhouse warming since 1750 (ref. 1). As such, it is important that all sources and sinks are fully quantified to include the role of terrestrial ecosystems in mediating atmospheric exchange. The global CH4 budget is now unbalanced, with sources ex
The development of LLMs is very involved and requires large quantities of training data. Yet, although current LLMs2,4,5,6, including GPT-3, were trained on predominantly human-generated text, this may change. If the training data of most future models are also scraped from the web, then they will inevitably train on data produced by their predecessors. In this paper, we investigate what happens w
Musical memory might be resistant to age-related cognitive declines because it stirs emotions and becomes more encoded in memory.Credit: SDI Productions/Getty The ability to remember and recognize a musical theme does not seem to be affected by age, unlike many other forms of memory. “You’ll hear anecdotes all the time of how people with severe Alzheimer’s can’t speak, can’t recognize people, but
While conspiracy theories are not new1,2, recent events have shown how dangerous and polarizing they can be in a globalized, mediatized world. Conspiracy theories undermined global efforts to contain the COVID-19 virus during the pandemic3,4 and were used in the lead-up to the January 6, 2021, raid on the Capitol1. They lie at the core of political and social polarization5,6, fueling vaccine skept
Barham, L. & Everett, D. Semiotics and the origin of language in the Lower Palaeolithic. J. Archaeol. Method Theory 28, 535–579 (2021). Article Google Scholar Hockett, C. F. The origin of speech. Sci. Am. 203, 88–97 (1960). A classic overview of the relationship between key features of human language and communication systems found in other species, with a focus on distinctive and shared propertie
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