PolyPhen (=Polymorphism Phenotyping) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations Fri Apr 6 17:30 EDT 2012: Dear PolyPhen users! Please be aware that this service has been discontinued and replaced with PolyPhen-2. (Click on the link above if you are not transfer