A nonredundant role for the adapter protein Shc in thymic T cell development (Q30309610)

16 June 2017

title

A nonredundant role for the adapter protein Shc in thymic T cell development (English)

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16 June 2017

Kodi S Ravichandran

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16 June 2017

Li Zhang

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16 June 2017

Victoria Camerini

series ordinal

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16 June 2017

Timothy P Bender

series ordinal

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16 June 2017

language of work or name

English

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publication date

8 July 2002

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16 June 2017

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16 June 2017

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16 June 2017

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16 June 2017

page(s)

749-755

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Branching out to gain control: how the pre-TCR is linked to multiple functions

16 June 2017

cites work

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7 January 2021

Pleiotropic changes controlled by the pre-T-cell receptor

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7 January 2021

Transgenic analysis of thymocyte signal transduction

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7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation

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7 January 2021

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte

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7 January 2021

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

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7 January 2021

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

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7 January 2021

Evolution of Shc functions from nematode to human

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7 January 2021

Signaling via Shc family adapter proteins

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7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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7 January 2021

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

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7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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7 January 2021

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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7 January 2021

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

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7 January 2021

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

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7 January 2021

Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

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7 January 2021

Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc

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7 January 2021

Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains

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7 January 2021

A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif

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7 January 2021

Integration of T cell receptor-dependent signaling pathways by adapter proteins

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7 January 2021

CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

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7 January 2021

Targeted oncogene activation by site-specific recombination in transgenic mice

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7 January 2021

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

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7 January 2021

Inducible gene targeting in mice

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7 January 2021

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

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7 January 2021

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

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7 January 2021

The role of membrane-associated adaptors in T cell receptor signalling

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7 January 2021

The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains

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7 January 2021

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

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7 January 2021

Interaction of Shc with Grb2 regulates the Grb2 association with mSOS

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7 January 2021

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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7 January 2021

The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases.

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7 January 2021

Identifiers

DOI

10.1038/NI820

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