The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 (Q28511655)

25 January 2017

title

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 (English)

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SOS Ras/Rac guanine nucleotide exchange factor 1

25 January 2017

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Growth factor receptor bound protein 2

GOA release 2020-03-11

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GOA release 2020-03-11

J. Wade

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M. Rozakis-Adcock

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25 January 2017

R. Fernley

series ordinal

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25 January 2017

T. Pawson

series ordinal

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25 January 2017

D. Bowtell

series ordinal

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25 January 2017

language of work or name

English

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publication date

6 May 1993

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25 January 2017

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25 January 2017

volume

363

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25 January 2017

issue

6424

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25 January 2017

page(s)

83–85

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Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

25 January 2017

cites work

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7 January 2021

Requirement for c-ras proteins during viral oncogene transformation

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7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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7 January 2021

Mechanistic aspects of signaling through Ras in NIH 3T3 cells

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7 January 2021

Insulin stimulation of gene expression mediated by p21ras activation.

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7 January 2021

Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities

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Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts

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7 January 2021

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

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7 January 2021

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

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7 January 2021

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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7 January 2021

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

1 reference

7 January 2021

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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7 January 2021

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

7 January 2021

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

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7 January 2021

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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7 January 2021

The Son of sevenless Gene Product: a Putative Activator of Ras

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7 January 2021

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

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7 January 2021

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins

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7 January 2021

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

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7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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7 January 2021

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

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7 January 2021

Solution structure of the SH3 domain of Src and identification of its ligand-binding site

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7 January 2021

Identification of a ten-amino acid proline-rich SH3 binding site

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7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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7 January 2021

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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7 January 2021

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

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7 January 2021

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

1 reference

7 January 2021

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

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7 January 2021