Proteins without unique 3D structures: biotechnological applications of intrinsically unstable/disordered proteins (Q38257180)

1 September 2017

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title

Proteins without unique 3D structures: biotechnological applications of intrinsically unstable/disordered proteins (English)

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1 September 2017

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Vladimir N Uversky

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1 September 2017

publication date

6 October 2014

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1 September 2017

published in

Biotechnology Journal

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1 September 2017

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1 September 2017

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1 September 2017

page(s)

356-366

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THE EFFECT OF DENATURATION ON THE VISCOSITY OF PROTEIN SYSTEMS

1 September 2017

cites work

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

On the Structure of Native, Denatured, and Coagulated Proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

"Partly folded" state, a new equilibrium state of protein molecules: four-state guanidinium chloride-induced unfolding of beta-lactamase at low temperature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Structures of folding intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Anion-induced folding of Staphylococcal nuclease: characterization of multiple equilibrium partially folded intermediates

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Denatured collapsed states in protein folding: example of apomyoglobin

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Protein folding revisited. A polypeptide chain at the folding ? misfolding ? nonfolding cross-roads: which way to go?

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Combining prediction, computation and experiment for the characterization of protein disorder

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Assessing protein disorder and induced folding

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsic disorder in cell-signaling and cancer-associated proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Coupling of folding and binding for unstructured proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically unstructured proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Natively unfolded proteins: a point where biology waits for physics

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

The unfoldomics decade: an update on intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Mechanism of coupled folding and binding of an intrinsically disordered protein

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsic disorder in scaffold proteins: getting more from less

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Function and structure of inherently disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

The protein trinity--linking function and disorder

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsic disorder and protein function

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Identification and functions of usefully disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

What does it mean to be natively unfolded?

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsic disorder and functional proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Alpha-synuclein misfolding and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Α-synuclein misfolding and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Biophysical characterization of α-synuclein and its controversial structure

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Understanding protein non-folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

NMR solution structure of the human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically disordered protein

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Sequence complexity of disordered protein

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Intrinsically disordered proteins and their environment: effects of strong denaturants, temperature, pH, counter ions, membranes, binding partners, osmolytes, and macromolecular crowding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Spectroscopic and chemical studies of the interaction between nerve growth factor (NGF) and the extracellular domain of the low affinity NGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Entropic elastic processes in protein mechanisms. I. Elastic structure due to an inverse temperature transition and elasticity due to internal chain dynamics

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Free energy transduction in polypeptides and proteins based on inverse temperature transitions

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Fusions of elastin-like polypeptides to pharmaceutical proteins.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Aqueous two-phase system formation kinetics for elastin-like polypeptides of varying chain length

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Natively unfolded human prothymosin alpha adopts partially folded collapsed conformation at acidic pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Heme binding and polymerization by Plasmodium falciparum histidine rich protein II: influence of pH on activity and conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Uncovering the unfoldome: enriching cell extracts for unstructured proteins by acid treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A novel two-dimensional electrophoresis technique for the identification of intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Proteomic studies of the intrinsically unstructured mammalian proteome.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400374

Comparing and combining predictors of mostly disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A cell cycle-regulated inhibitor of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Effect of zinc and temperature on the conformation of the gamma subunit of retinal phosphodiesterase: a natively unfolded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Physicochemical characterization of the heat-stable microtubule-associated protein MAP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Elastin‐Like Polypeptides as a Purification Tag for Recombinant Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Single-step purification of recombinant proteins using elastin-like peptide-mediated inverse transition cycling and self-processing module from Neisseria meningitides FrpC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Kinetic quantification of protein polymer nanoparticles using non-invasive imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Cell penetrating elastin-like polypeptides for therapeutic peptide delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Structural and hydrodynamic analysis of a novel drug delivery vector: ELP[V5G3A2-150].

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Polypentapeptide of elastin: temperature dependence of ellipticity and correlation with elastomeric force

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Characterization of the temperature- and pressure-induced inverse and reentrant transition of the minimum elastin-like polypeptide GVG(VPGVG) by DSC, PPC, CD, and FT-IR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Effect of basic cell-penetrating peptides on the structural, thermodynamic, and hydrodynamic properties of a novel drug delivery vector, ELP[V5G3A2-150].

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Thermally targeted p21 peptide enhances bortezomib cytotoxicity in androgen-independent prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A thermally responsive Tat-elastin-like polypeptide fusion protein induces membrane leakage, apoptosis, and cell death in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Protocol for preparing proteins with improved solubility by co-expressing with molecular chaperones in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Multiple joined genes prevent product degradation in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Secretion of heterologous gene products to the culture medium of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Structural analysis of regulatory protein domains using GST-fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Protein aggregation during overexpression limited by peptide extensions with large net negative charge

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

Sweeping away protein aggregation with entropic bristles: intrinsically disordered protein fusions enhance soluble expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

de novo computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

De novo protein design: towards fully automated sequence selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

De Novo Protein Design: Fully Automated Sequence Selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

The Chemistry of Protein Denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400374

21 January 2018

Identifiers

DOI

10.1002/BIOT.201400374

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1 September 2017

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