A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions (Q24294366)

5 July 2017

title

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions (English)

1 reference

5 July 2017

1 reference

cell-cell adhesion

1 reference

Presenilin 1

1 reference

Matrix metallopeptidase 13

1 reference

Cadherin 1

1 reference

Philippe Marambaud

Philippe

Marambaud

1 reference

19 October 2023

Junichi Shioi

Junichi

Shioi

1 reference

5 July 2017

Geo Serban

Geo

Serban

1 reference

5 July 2017

Anastasios Georgakopoulos

Anastasios

Georgakopoulos

1 reference

5 July 2017

Shula Sarner

Shula

Sarner

1 reference

5 July 2017

Vanja Nagy

Vanja

Nagy

1 reference

5 July 2017

Lia Baki

Lia

Baki

1 reference

5 July 2017

Paul Wen

Paul

Wen

1 reference

5 July 2017

Spiros Efthimiopoulos

Spiros

Efthimiopoulos

1 reference

5 July 2017

Zhiping Shao

Zhiping

Shao

1 reference

5 July 2017

Thomas Wisniewski

Thomas

Wisniewski

1 reference

5 July 2017

Nikolaos K Robakis

Nikolaos K

Robakis

1 reference

5 July 2017

language of work or name

English

0 references

publication date

1 April 2002

1 reference

5 July 2017

1 reference

5 July 2017

1 reference

5 July 2017

1 reference

5 July 2017

page(s)

1948-1956

1 reference

Regulation of cadherin adhesive activity

5 July 2017

cites work

1 reference

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Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

19 March 2017

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

19 March 2017

1 reference

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19 March 2017

Wnt signaling and cancer

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Alzheimer's disease: genes, proteins, and therapy

19 March 2017

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

19 March 2017

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

19 March 2017

1 reference

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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation

19 March 2017

1 reference

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Differential brain expression of the Alzheimer's amyloid precursor protein

19 March 2017

1 reference

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E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

19 March 2017

1 reference

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

24 March 2017

1 reference

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A portrait of Alzheimer secretases--new features and familiar faces

27 September 2017

1 reference

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Sticking together and sorting things out: adhesion as a force in development

27 September 2017

1 reference

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Cadherins in embryonic and neural morphogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.

27 September 2017

1 reference

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Cleavage and shedding of E-cadherin after induction of apoptosis

27 September 2017

1 reference

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

27 September 2017

1 reference

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Molecular modification of N-cadherin in response to synaptic activity

27 September 2017

1 reference

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Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Truncation of the beta-catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Cadherins and their connections: adhesion junctions have broader functions.

27 September 2017

1 reference

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Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

27 September 2017

1 reference

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The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Inhibition of beta-catenin-mediated transactivation by cadherin derivatives

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases

27 September 2017

1 reference

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Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

27 September 2017

1 reference

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A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Uncoupling cadherin-based adhesion from wingless signalling in Drosophila.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Low molecular weight inhibitors in corneal ulceration

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125968

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11953314

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11953314

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11953314

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/21.8.1948

1 reference

release_jpeovc5dafbyfhssceankevjzm

5 July 2017

Fatcat ID

0 references

OpenCitations bibliographic resource ID

1084723

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

5 July 2017

1 reference