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Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate network of inter-chromosomal transcription hub structures.
Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit fly model with mitochondrial dysfunction.
The authors present that encephalitic Semliki Forest virus uses choroid plexus epithelial cells as neuroinvasion pathway in mice and show that entry is specifically dependent on expression of very low-density-lipoprotein receptor in these cells.
The extracellular matrix is remodeled to form complex interconnected network structures that regulate stem cell behaviors. Here, the authors modulate extracellular matrix-like networks using magnetic nano-blockers, adjusting stem cell behavior by changing ligand inter-cluster connectivity. This dynamic system provides new insights into cell-material interactions for tissue regeneration.
Bellou et al. show that acrocentric chromosomes, such as chromosome 21, are more prone to aneuploidy in oocytes due to their unique architecture and lower cohesion levels, which lead to inefficient alignment and increased mis-segregation during meiosis.
Reduced flexibility is a hallmark of cognitive ageing. Here, the authors examine EEG, fMRI and pupillometry signatures to show that older adults adapt less to variable uncertainty and identify neural mechanisms that support uncertainty adjustment in aging populations.
While silicon is a crucial semiconducting material, solution-based synthetic approaches for unsaturated silicon-rich molecules require less efficient multi-step syntheses. Here, the authors report access to soluble, polyhedral Si9 clusters from the binary phase K12Si17, which contains both [Si4]4− and [Si9]4− clusters.
The Atlantic herring is one of the world’s most abundant vertebrates and a typical plankton feeder of major ecological importance. This study shows that a piscivorous (fish-eating) ecotype of herring has evolved after the colonization of the brackish Baltic Sea within the last 8,000 years.
8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants of 8-oxoG-induced mutation and the mechanisms involved in the repair of KBrO3-induced 8-oxoG.
Three-dimensional genome organization is important for transcription regulation. Here the authors show that microRNA 9 mediates the formation of G-quadruplexes and the looping of promoters and super-enhancers in genes activated by transforming growth factor beta 1signaling.
As anthropogenic forcing increases in the future, Southern Hemisphere atmospheric variability, the Southern Annular Mode, plays a more significant role in Antarctic sea ice variability than the deep convection in the Southern Ocean.
Inducible promoters that control gene expression in response to small molecules are essential in synthetic biology. Here, the authors describe a simple and reliable approach for constructing strongly inducible synthetic yeast promoters, which are validated for use in large-scale protein production.
Bats are a likely reservoir of zoonotic coronaviruses (CoVs). Here, analyzing bat CoV sequences in China, the authors find that alpha-CoVs have switched hosts more frequently than betaCoVs, identify a bat family and genus that are highly involved in host-switching, and define hotspots of CoV evolutionary diversity.
