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Cells
Special Issues
New Discoveries in Calcium Signaling-Related Neurological Disorders
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New Discoveries in Calcium Signaling-Related Neurological Disorders

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 543

Special Issue Editor

Dr. Matheus De Castro Fonseca

E-Mail Website
Guest Editor
Laboratory of Sarkis Mazmanian, Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA
Interests: microbiome; Ca2+ signaling; Parkinson’s disease; protein aggregation; brain physiology

Special Issue Information

Dear Colleagues,

The ubiquitous intracellular messenger calcium (Ca2+) exerts regulatory control over virtually every activity in eukaryotic cells, particularly in excitable cells. Within neurons, Ca2+ assumes a crucial role in the regulation and modulation of essential physiological processes, spanning from synaptic activity to neuronal plasticity. Given the necessity for a highly refined and precise control of Ca2+ levels within specific cellular compartments in neurons, the organizational structure of the Ca2+ signaling machinery in neurons is notably intricate. The malfunctioning of the Ca2+ signaling pathway, which oversees numerous neuronal processes, has been linked to the onset and progression of significant neural disorders in humans. Conditions such as Alzheimer's disease, bipolar disorder, and schizophrenia have been implicated in instances where the Ca2+ signaling pathway experiences dysregulation.

This Special Issue aims to put together all the recent findings on how Ca2+ dysregulation can contribute to the outcome and progression of several neurological disorders.

Dr. Matheus De Castro Fonseca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ca2+ signaling
  • neurons
  • neurological disorders
  • intracellular signaling
  • synaptic dysfunction

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Review

18 pages, 1835 KiB  
Review
Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy
by Dechuan Sun, Mona Amiri, Qi Meng, Ranjith R. Unnithan and Chris French
Cells 2025, 14(1), 4; https://doi.org/10.3390/cells14010004 - 25 Dec 2024
Abstract
Neurological disorders (NDs), such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and schizophrenia, represent a complex and multifaceted health challenge that affects millions of people around the world. Growing evidence suggests that disrupted neuronal calcium signalling [...] Read more.
Neurological disorders (NDs), such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and schizophrenia, represent a complex and multifaceted health challenge that affects millions of people around the world. Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. Additionally, calcium functions as a ubiquitous second messenger involved in diverse cellular processes, from synaptic activity to intercellular communication, making it a potential therapeutic target. Recently, the development of the miniature fluorescence microscope (miniscope) enabled simultaneous recording of the spatiotemporal calcium activity from large neuronal ensembles in unrestrained animals, providing a novel method for studying NDs. In this review, we discuss the abnormalities observed in calcium signalling and its potential as a therapeutic target for NDs. Additionally, we highlight recent studies that utilise miniscope technology to investigate the alterations in calcium dynamics associated with NDs. Full article
(This article belongs to the Special Issue New Discoveries in Calcium Signaling-Related Neurological Disorders)
►▼ Show Figures

Figure 1

Figure 1
<p>A typical structure of a conventional fluorescence microscope and the miniscope. (<b>a</b>) Conventional fluorescence microscope. (<b>b</b>) Miniscope: An LED emits light at a wavelength that excites the fluorophore, which is collimated by a half-ball lens. The excitation light passes through an excitation filter to reduce background noise before being reflected by a dichroic mirror. A GRIN lens focuses the light to activate fluorophores in neurons and collects the fluorescent signals. These signals are then directed back through the dichroic mirror and an emission filter, isolating the desired wavelength. Then, an achromatic lens focuses the signals onto a CMOS sensor.</p> Full article ">Figure 2
<p>The miniscope facilitates the recording of neuronal calcium signals in freely moving mice. (<b>a</b>) An example of a C57BL/6 mouse wearing the UCLA miniscope (version 3). (<b>b</b>) A representative image showing hippocampal CA1 neurons captured using the miniscope. Neurons are labelled with GCamp6f. Typically, over 100 neurons can be observed within the field of view.</p> Full article ">Figure 3
<p>An example of using the miniscope to study the calcium activity of hippocampal neurons in mice. (<b>a</b>) A mouse wearing a miniscope traverses a linear track. (<b>b</b>) An example showing that the calcium activity of hippocampal neurons exhibits spatial sensitivity when mice traverse a linear track. (<b>c</b>) An example of raw fluorescent intensity in the detected neurons captured by the miniscope. (<b>d</b>) An example of a neuron’s deconvolved calcium activity.</p> Full article ">
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Displaying articles 1-1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Calcium Signalling in Neurological Disorders with Insights from Miniature Fluorescence Microscopy
Authors: Dechuan Sun; Mona Amiri; Qi Meng; Ranjith R Unnithan; Chris French
Affiliation: The University of Melbourne
Abstract: Neurological disorders (NDs), such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and schizophrenia, represent a complex and multifaceted health challenge that affects millions of people around the world. Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. Additionally, calcium functions as a ubiquitous second messenger involved in diverse cellular processes, from synaptic activity to intercellular communication, making it a potential therapeutic target. Recently development of the miniature fluorescence microscope (miniscope) enables simultaneous recording of spatiotemporal calcium activity from large neuronal ensembles in unrestrained animals, providing a novel method for studying NDs. In this review, we discuss the abnormalities observed in calcium signalling and its potential as a therapeutic target for NDs. Additionally, we highlight recent studies that utilize miniscope technology to investigate alterations in calcium dynamics associated with NDs.

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