 | | DRUG: dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea | |
| Entry |
|
|---|
| Name |
dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea;
Coughcode N (TN) |
|---|
| Component |
dl-Methylephedrine hydrochloride [DR: D02109], Dihydrocodeine phosphate [DR: D01481], Diprophylline [DR: D00691], Diphenhydramine salicylate [DR: D02419], Acetaminophen [DR: D00217], Bromovalerylurea [DR: D01391]
|
|---|
| Class |
|
|---|
| Remark |
| Therapeutic category: | 2229 |
|
|---|
| Efficacy |
Analgesic, Antipyretic, Antitussive |
|---|
| Comment |
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
|
|---|
| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA58 Dihydrocodeine, combinations
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
222 Antitussives
2229 Others
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
DG02924 UGT substrate
DG03189 UGT2B4 substrate
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
DG03190 UGT2B7 substrate
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Unclassified
DG03282 Ephedrine-containing preparation
D08695 dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08695
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
|
» Japanese version » Back
|