Table of Contents

Drug Discovery and Translational Medicine

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  Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment

  Fábio H. Silva, Serkan Karakus, Biljana Musicki, Hotaka Matsui, Trinity J. Bivalacqua, Jean L. dos Santos, Fernando F. Costa and Arthur L. Burnett

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 230-237; DOI: https://doi.org/10.1124/jpet.116.235473
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  High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer

  Winston Vuong, Ben Y. Tew, Gillian H. Little, Baruch Frenkel and Jeremy O. Jones

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 256-261; DOI: https://doi.org/10.1124/jpet.116.234567
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  Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke

  HyeonJu Kim, Ying Wei, Ji Yong Lee, Yue Wu, Yi Zheng, Michael A. Moskowitz and John W. Chen

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 262-272; DOI: https://doi.org/10.1124/jpet.116.235127
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  Renal Effects of Antisense-Mediated Inhibition of SGLT2

  Leonie van Meer, Matthijs Moerland, Marloes van Dongen, Bas Goulouze, Marieke de Kam, Erica Klaassen, Adam Cohen and Jacobus Burggraaf

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 280-289; DOI: https://doi.org/10.1124/jpet.116.233809
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  Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy

  Mark R. Kelley, James H. Wikel, Chunlu Guo, Karen E. Pollok, Barbara J. Bailey, Randy Wireman, Melissa L. Fishel and Michael R. Vasko

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 300-309; DOI: https://doi.org/10.1124/jpet.116.235283
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  Positive Allosteric Modulation of the Muscarinic M₁ Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior

  Kwok H. C. Choy, David M. Shackleford, Daniel T. Malone, Shailesh N. Mistry, Rahul T. Patil, Peter J. Scammells, Christopher J. Langmead, Christos Pantelis, Patrick M. Sexton, Johnathan R. Lane and Arthur Christopoulos

  Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 354-365; DOI: https://doi.org/10.1124/jpet.116.235788