Table of Contents

October 01, 2016; Volume 359,Issue 1

Minireview

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Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps
Joseph A. Cichocki, Kathryn Z. Guyton, Neela Guha, Weihsueh A. Chiu, Ivan Rusyn and Lawrence H. Lash

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 110-123; DOI: https://doi.org/10.1124/jpet.116.232629

Behavioral Pharmacology

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Discriminative Stimulus Effects of Binary Drug Mixtures: Studies with Cocaine, MDPV, and Caffeine
Gregory T. Collins, Megan Abbott, Kayla Galindo, Elise L. Rush, Kenner C. Rice and Charles P. France

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 1-10; DOI: https://doi.org/10.1124/jpet.116.234252
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New Morphine Analogs Produce Peripheral Antinociception within a Certain Dose Range of Their Systemic Administration
Erzsébet Lackó, Pál Riba, Zoltán Giricz, András Váradi, Laura Cornic, Mihály Balogh, Kornél Király, Kata Csekő, Shaaban A. Mousa, Sándor Hosztafi, Michael Schäfer, Zoltán Sándor Zádori, Zsuzsanna Helyes, Péter Ferdinandy, Susanna Fürst and Mahmoud Al-Khrasani

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 171-181; DOI: https://doi.org/10.1124/jpet.116.233551

Cardiovascular

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Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions
Shahrooz Nasrollahi-Shirazi, Sonja Sucic, Qiong Yang, Michael Freissmuth and Christian Nanoff

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 73-81; DOI: https://doi.org/10.1124/jpet.116.232884
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats
Christopher M. Harris, Scott Mittelstadt, Patricia Banfor, Peter Bousquet, David B. Duignan, Gary Gintant, Michelle Hart, Youngjae Kim and Jason Segreti

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 151-158; DOI: https://doi.org/10.1124/jpet.116.235002
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The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter’s Syndrome Type II Phenotype
Caryn Hampton, Xiaoyan Zhou, Birgit T. Priest, Lee-Yuh Pai, John P. Felix, Brande Thomas-Fowlkes, Jessica Liu, Martin Kohler, Jianying Xiao, Aaron Corona, Olga Price, Charles Gill, Kashmira Shah, Cordelia Rasa, Vince Tong, Karen Owens, James Ormes, Haifeng Tang, Sophie Roy, Kathleen A. Sullivan, Joseph M. Metzger, Magdalena Alonso-Galicia, Gregory J. Kaczorowski, Alexander Pasternak and Maria L. Garcia

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 194-206; DOI: https://doi.org/10.1124/jpet.116.235150

Cellular and Molecular

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The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis
Ji Zhou, Wenjie You, Guangqiang Sun, Yixuan Li, Bi Chen, Jing Ai and Handong Jiang

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 54-61; DOI: https://doi.org/10.1124/jpet.116.234799
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Positive and Negative Cross-Talk between Lysophosphatidic Acid Receptor 1, Free Fatty Acid Receptor 4, and Epidermal Growth Factor Receptor in Human Prostate Cancer Cells
Mandi M. Hopkins, Ze Liu and Kathryn E. Meier

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 124-133; DOI: https://doi.org/10.1124/jpet.116.233379

Drug Discovery and Translational Medicine

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Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis
Haoming Zhang, D. Adam Lauver, Hui Wang, Duxin Sun, Paul F. Hollenberg, Y. Eugene Chen, Yoichi Osawa and Daniel T. Eitzman

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 11-17; DOI: https://doi.org/10.1124/jpet.116.236034
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Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function
Jahnabi Roy, Reheman Adili, Richard Kulmacz, Michael Holinstat and Aditi Das

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 134-141; DOI: https://doi.org/10.1124/jpet.116.234781
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Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates
Steven M. Weldon, Matthew A. Cerny, Kristina Gueneva-Boucheva, Derek Cogan, Xin Guo, Neil Moss, Jean-Hugues Parmentier, Jeremy R. Richman, Glenn A. Reinhart and Nicholas F. Brown

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 142-150; DOI: https://doi.org/10.1124/jpet.116.236463

Endocrine and Diabetes

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Empagliflozin Protects against Diet-Induced NLRP-3 Inflammasome Activation and Lipid Accumulation
Elisa Benetti, Raffaella Mastrocola, Giovanna Vitarelli, Juan Carlos Cutrin, Debora Nigro, Fausto Chiazza, Eric Mayoux, Massimo Collino and Roberto Fantozzi

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 45-53; DOI: https://doi.org/10.1124/jpet.116.235069

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, Aik Jiang Lau, Laurie Alston, Thomas K. H. Chang, Sridhar Mani and Simon A. Hirota

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 91-101; DOI: https://doi.org/10.1124/jpet.116.234096
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Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis
Kannan Thirunavukkarasu, Bailin Tan, Craig A. Swearingen, Guilherme Rocha, Hai H. Bui, Denis J. McCann, Spencer B. Jones, Bryan H. Norman, Lance A. Pfeifer and Joy K. Saha

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 207-214; DOI: https://doi.org/10.1124/jpet.116.234013

Inflammation, Immunopharmacology, and Asthma

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Unexpected Potency Differences between B-Cell–Activating Factor (BAFF) Antagonist Antibodies against Various Forms of BAFF: Trimer, 60-Mer, and Membrane-Bound
Amy M. Nicoletti, Cynthia Hess Kenny, Ashraf M. Khalil, Qi Pan, Kerry L. M. Ralph, Julie Ritchie, Sathyadevi Venkataramani, David H. Presky, Scott M. DeWire and Scott R. Brodeur

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 37-44; DOI: https://doi.org/10.1124/jpet.116.236075

Metabolism, Transport, and Pharmacogenomics

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Intracellular Unbound Atorvastatin Concentrations in the Presence of Metabolism and Transport
Priyanka Kulkarni, Kenneth Korzekwa and Swati Nagar

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 26-36; DOI: https://doi.org/10.1124/jpet.116.235689
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Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance–Associated Protein 3 Activation through a Novel Transcriptional Element
Takamitsu Sasaki, Keita Inami, Yoshihiro Numata, Kodai Funakoshi, Midori Yoshida, Takeshi Kumagai, Shuichi Kanno, Satomi Matsui, Takayoshi Toriyabe, Yasushi Yamazoe, Kouichi Yoshinari and Kiyoshi Nagata

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 102-109; DOI: https://doi.org/10.1124/jpet.115.231589
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Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines
Douglas F. Dluzen, Aimee K. Sutliff, Gang Chen, Christy J. W. Watson, Faoud T. Ishmael and Philip Lazarus

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 182-193; DOI: https://doi.org/10.1124/jpet.116.235044
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Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach
Henry C. Liu, Anne Goldenberg, Yuchen Chen, Christina Lun, Wei Wu, Kevin T. Bush, Natasha Balac, Paul Rodriguez, Ruben Abagyan and Sanjay K. Nigam

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 215-229; DOI: https://doi.org/10.1124/jpet.116.232660

Neuropharmacology

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Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels
Florian Schillers, Esther Eberhardt, Andreas Leffler and Mirjam Eberhardt

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 18-25; DOI: https://doi.org/10.1124/jpet.116.233452
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In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
Niina Aaltonen, Ewa Kedzierska, Jolanta Orzelska-Górka, Marko Lehtonen, Dina Navia-Paldanius, Hermina Jakupovic, Juha R. Savinainen, Tapio Nevalainen, Jarmo T. Laitinen, Teija Parkkari and Mikko Gynther

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 62-72; DOI: https://doi.org/10.1124/jpet.116.233114
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Inhibition of CaMKIIα in the Central Nucleus of Amygdala Attenuates Fentanyl-Induced Hyperalgesia in Rats
Zhen Li, Chenhong Li, Pingping Yin, Zaijie Jim Wang and Fang Luo

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 82-89; DOI: https://doi.org/10.1124/jpet.116.233817
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Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters
Adem Can, Panos Zanos, Ruin Moaddel, Hye Jin Kang, Katinia S. S. Dossou, Irving W. Wainer, Joseph F. Cheer, Douglas O. Frost, Xi-Ping Huang and Todd D. Gould

Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 159-170; DOI: https://doi.org/10.1124/jpet.116.235838

Notice of Retraction

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Re: Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schönfeld P, Roessner A, and Gali-Muhtasib H (2005) 5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms. J Pharmacol Exp Ther February 2005 312:525–536; doi:10.1124/jpet.104.074195
Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 90; DOI: https://doi.org/10.1124/jpet.113.074195retraction

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Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Notice of Retraction

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