Arahidonat 5-lipoksigenaza (EC 1.13.11.34, leukotrien-A4 sintaza, Delta5-lipoksigenaza, 5Delta-lipoksigenaza, arahidonska 5-lipoksigenaza, arahidonska kiselina 5-lipoksigenaza, C-5-lipoksigenaza, LTA sintaza, leukotrienska A4 sintaza) je enzim sa sistematskim imenom arachidonat:kiseonik 5-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- arahidonat + O2
leukotrien A4 + H2O (sveukupna reakcija)
- (1a) arahidonat + O2 (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat
- (1b) (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat leukotrien A4 +H2O
- ↑ Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 85: 26-30. PMID 2829172.
- ↑ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers”. J. Biol. Chem. 262: 10200-10205. PMID 3038871.
- ↑ Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 83: 4175-4179. PMID 3012557.
- ↑ Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA 81: 689-693. PMID 6322165.
