An imagable and photothermal "Abraxane-like" nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors

Adv Mater. 2015 Feb 4;27(5):903-10. doi: 10.1002/adma.201404308. Epub 2014 Dec 12.

Authors

Qian Chen¹, Chao Liang, Chao Wang, Zhuang Liu

Affiliation

¹ Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, Jiangsu, 215123, China.

PMID: 25504416
DOI: 10.1002/adma.201404308

Abstract

A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-of-concept study.

Keywords: combination therapy; human serum albumin; indocyanine green; lung metastasis; paclitaxel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albumin-Bound Paclitaxel
Albumins / chemistry
Albumins / therapeutic use
Breast Neoplasms / diagnosis
Breast Neoplasms / drug therapy
Breast Neoplasms / pathology*
Breast Neoplasms / therapy
Cell Line, Tumor
Chemistry, Pharmaceutical
Drug Therapy, Combination
Female
Humans
Indocyanine Green / chemistry
Models, Molecular
Nanoparticles / chemistry
Nanoparticles / therapeutic use*
Neoplasm Metastasis
Paclitaxel / chemistry
Paclitaxel / therapeutic use*
Phototherapy / methods*
Protein Conformation
Subcutaneous Tissue / pathology*

Substances

Albumin-Bound Paclitaxel
Albumins
Indocyanine Green
Paclitaxel