Abstract
We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II-restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / therapeutic use*
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Antigen-Presenting Cells / immunology
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Antigen-Presenting Cells / metabolism
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Binding Sites, Antibody
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Cytotoxicity, Immunologic*
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Epitopes / immunology
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Humans
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Mice
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Species Specificity
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antibodies, Monoclonal
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Epitopes