Abstract
Hematopoiesis - the process by which blood cells are formed - has been studied intensely for over a century using a variety of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist. Over the last decade, the zebrafish has come to the forefront as a new model in hematopoiesis research, as it allows the use of large-scale genetics, chemical screens and transgenics. This comparative approach to understanding hematopoiesis has led to fundamental knowledge about the process and to the development of new therapies for disease. Here, we provide a broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model.
Keywords:
Hematopoiesis; Mouse; Zebrafish.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Core Binding Factor Alpha 2 Subunit / genetics
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Core Binding Factor Alpha 2 Subunit / metabolism
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Embryonic Development
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GATA1 Transcription Factor / genetics
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GATA1 Transcription Factor / metabolism
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Gene Expression Regulation, Developmental*
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Hemangioblasts / cytology
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Hemangioblasts / metabolism
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Hematopoiesis*
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Hematopoietic Stem Cell Transplantation
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / metabolism
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Humans
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Prostaglandins / metabolism
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Wnt Signaling Pathway
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Zebrafish / blood*
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Zebrafish / metabolism
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Zebrafish Proteins / genetics
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Zebrafish Proteins / metabolism
Substances
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Core Binding Factor Alpha 2 Subunit
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GATA1 Transcription Factor
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Prostaglandins
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Zebrafish Proteins
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gata1a protein, zebrafish
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runx1 protein, zebrafish