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Microdrop printing of hydrogel bioinks into 3D tissue-like geometries

Adv Mater. 2012 Jan 17;24(3):391-6. doi: 10.1002/adma.201102800. Epub 2011 Dec 12.

Abstract

An optimized 3D inkjet printing process is demonstrated for structuring alginate into a tissue-like microvasculature capable of supporting physiological flow rates. Optimizing the reaction at the single-droplet level enables wet hydrogel droplets to be stacked, thus overcoming their natural tendancy to spread and coalesce. Live cells can be patterned using this process and it can be extended to a range of other hydrogels.

Keywords: biofabrication; capillaries; hydrogels; inkjet printing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates / chemistry
  • Animals
  • Biomimetics / methods*
  • Collagen / chemistry
  • Gelatin / chemistry
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Hydrodynamics
  • Hydrogels*
  • Ink*
  • Mice
  • Microtechnology / methods*
  • NIH 3T3 Cells
  • Printing / methods*

Substances

  • Alginates
  • Hexuronic Acids
  • Hydrogels
  • Glucuronic Acid
  • Gelatin
  • Collagen