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Reversal of fibrosis: no longer a pipe dream?

Clin Liver Dis. 2006 Aug;10(3):481-97, viii. doi: 10.1016/j.cld.2006.08.022.

Abstract

The reversal of liver fibrosis is not a new phenomenon. Treatment of the primary disease remains the most effective strategy, but new approaches to promote resolution of fibrosis are being built on the foundations that were provided by research into the basic mechanisms of fibrogenesis. A return to normal hepatic architecture from advanced fibrosis is achievable in some cases, and cirrhosis itself may be partly remediable.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Extracellular Matrix / pathology
  • Hepatocytes / pathology
  • Humans
  • Liver Cirrhosis / pathology*
  • Liver Cirrhosis / therapy*

Substances

  • Anti-Inflammatory Agents
  • Antioxidants