Abstract
The estrogen receptors ERalpha and ERbeta are the main mediators of estrogen action and estrogens play an important role in a variety of aspects of physiology besides their well acknowledged function in reproduction. In vivo and in vitro studies indicate that the estrogen receptors are mechanistically implicated in endocrine-related diseases. Recent studies with estrogen receptor knockout mice have helped to unravel the role of the estrogen receptors in brain degeneration, osteoporosis, cardiovascular diseases and obesity.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adipose Tissue / metabolism
-
Animals
-
Bone and Bones / metabolism
-
Brain / metabolism
-
Cardiovascular Diseases / etiology
-
Cardiovascular Diseases / metabolism
-
Cardiovascular System / metabolism
-
Endocrine System Diseases / etiology*
-
Endocrine System Diseases / metabolism
-
Estrogen Receptor alpha
-
Estrogen Receptor beta
-
Mice
-
Mice, Knockout
-
Neurodegenerative Diseases / etiology
-
Neurodegenerative Diseases / metabolism
-
Obesity / etiology
-
Obesity / metabolism
-
Osteoporosis / etiology
-
Osteoporosis / metabolism
-
Receptors, Estrogen / genetics
-
Receptors, Estrogen / metabolism
-
Receptors, Estrogen / physiology*
Substances
-
Estrogen Receptor alpha
-
Estrogen Receptor beta
-
Receptors, Estrogen