Abstract
Atomic force microscopy of single molecules, steered molecular dynamics and the theory of stochastic processes have established a new field that investigates mechanical functions of proteins, such as ligand-receptor binding/unbinding and elasticity of muscle proteins during stretching. The combination of these methods yields information on the energy landscape that controls mechanical function and on the force-bearing components of proteins, as well as on the underlying physical mechanisms.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Avidin / chemistry
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Avidin / metabolism
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Biotin / chemistry
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Biotin / metabolism
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Computer Simulation
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Connectin
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Fibronectins / chemistry
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Fibronectins / metabolism
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Immunoglobulins / chemistry
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Immunoglobulins / metabolism
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Microscopy, Atomic Force / methods*
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Muscle Proteins / chemistry
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Muscle Proteins / metabolism
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Protein Kinases / chemistry
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Protein Kinases / metabolism
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Protein Structure, Tertiary
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Proteins / chemistry*
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Proteins / metabolism*
Substances
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Connectin
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Fibronectins
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Immunoglobulins
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Muscle Proteins
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Proteins
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Avidin
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Biotin
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Protein Kinases