Abstract
Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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DNA, Bacterial / metabolism*
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Escherichia coli / genetics*
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Fimbriae, Bacterial / chemistry*
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Forecasting
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Gene Expression Regulation, Bacterial / genetics*
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Methylation
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Models, Molecular
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Operon / genetics*
Substances
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Bacterial Proteins
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DNA, Bacterial