ZA992941B - Benzothiophene, benzofuran and indole compounds, a process for their preparation and pharmaceutical compositions containing them. - Google Patents
Benzothiophene, benzofuran and indole compounds, a process for their preparation and pharmaceutical compositions containing them.Info
- Publication number
- ZA992941B ZA992941B ZA9902941A ZA992941A ZA992941B ZA 992941 B ZA992941 B ZA 992941B ZA 9902941 A ZA9902941 A ZA 9902941A ZA 992941 A ZA992941 A ZA 992941A ZA 992941 B ZA992941 B ZA 992941B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- optionally substituted
- heterocyclic ring
- bond
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9805239A FR2777886B1 (fr) | 1998-04-27 | 1998-04-27 | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA992941B true ZA992941B (en) | 1999-10-26 |
Family
ID=9525701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9902941A ZA992941B (en) | 1998-04-27 | 1999-04-26 | Benzothiophene, benzofuran and indole compounds, a process for their preparation and pharmaceutical compositions containing them. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6048875A (xx) |
| EP (1) | EP0955299B1 (xx) |
| JP (1) | JP3957424B2 (xx) |
| CN (1) | CN1211362C (xx) |
| AT (1) | ATE214387T1 (xx) |
| AU (1) | AU744456B2 (xx) |
| BR (1) | BR9901298A (xx) |
| CA (1) | CA2270086C (xx) |
| DE (1) | DE69901006T2 (xx) |
| DK (1) | DK0955299T3 (xx) |
| ES (1) | ES2174579T3 (xx) |
| FR (1) | FR2777886B1 (xx) |
| HK (1) | HK1022694A1 (xx) |
| HU (1) | HUP9901403A1 (xx) |
| NO (1) | NO319101B1 (xx) |
| NZ (1) | NZ335388A (xx) |
| PT (1) | PT955299E (xx) |
| ZA (1) | ZA992941B (xx) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162930A (en) * | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1263763B1 (en) | 2000-03-10 | 2007-07-25 | Baylor University | Tubulin binding ligands |
| WO2002096416A1 (en) * | 2001-05-31 | 2002-12-05 | Cellegy Pharmaceuticals, Inc. | Store operated calcium influx inhibitors and methods of use |
| ES2290318T3 (es) * | 2001-06-20 | 2008-02-16 | Wyeth | Derivados sustituidos de acido indolico como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1). |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| EP1569899B1 (en) * | 2002-12-10 | 2006-06-28 | Wyeth | Substituted 3-alkyl- and 3-arylalkyl-1h-indol-1-yl-acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| ES2266907T3 (es) * | 2002-12-10 | 2007-03-01 | Wyeth | Derivados sustituidos del acido 3-carbonil-indol-1-il-acetico como inhibidor del activador del plasminogeno-1 (pal-1). |
| EP1569901B1 (en) | 2002-12-10 | 2008-10-15 | Wyeth | ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
| BR0316584A (pt) * | 2002-12-10 | 2005-10-04 | Wyeth Corp | Derivados de ácido acético indol oxo-acetil amino substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| AU2005277139A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| BRPI0514549A (pt) | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| US7754747B2 (en) | 2004-08-23 | 2010-07-13 | Wyeth Llc | Oxazolo-naphthyl acids |
| BRPI0614340A2 (pt) * | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
| ATE531720T1 (de) * | 2006-08-21 | 2011-11-15 | Genentech Inc | Aza-benzofuranylverbindungen und anwendungsverfahren dafür |
| JP5349306B2 (ja) * | 2006-08-21 | 2013-11-20 | ジェネンテック， インコーポレイテッド | アザベンゾチオフェニル化合物および使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663344A (en) * | 1985-03-11 | 1987-05-05 | Merck & Co., Inc. | Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor |
| IT1227362B (it) * | 1988-11-18 | 1991-04-08 | Istituto Biochimico Italiano | Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
-
1998
- 1998-04-27 FR FR9805239A patent/FR2777886B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-23 NO NO19991957A patent/NO319101B1/no unknown
- 1999-04-26 EP EP99401010A patent/EP0955299B1/fr not_active Expired - Lifetime
- 1999-04-26 DK DK99401010T patent/DK0955299T3/da active
- 1999-04-26 JP JP11736799A patent/JP3957424B2/ja not_active Expired - Fee Related
- 1999-04-26 CA CA002270086A patent/CA2270086C/fr not_active Expired - Fee Related
- 1999-04-26 ZA ZA9902941A patent/ZA992941B/xx unknown
- 1999-04-26 DE DE69901006T patent/DE69901006T2/de not_active Expired - Fee Related
- 1999-04-26 US US09/299,271 patent/US6048875A/en not_active Expired - Fee Related
- 1999-04-26 NZ NZ335388A patent/NZ335388A/xx unknown
- 1999-04-26 AT AT99401010T patent/ATE214387T1/de not_active IP Right Cessation
- 1999-04-26 ES ES99401010T patent/ES2174579T3/es not_active Expired - Lifetime
- 1999-04-26 PT PT99401010T patent/PT955299E/pt unknown
- 1999-04-27 CN CNB991051815A patent/CN1211362C/zh not_active Expired - Fee Related
- 1999-04-27 HU HU9901403A patent/HUP9901403A1/hu unknown
- 1999-04-27 BR BR9901298-7A patent/BR9901298A/pt not_active Application Discontinuation
- 1999-04-27 AU AU24021/99A patent/AU744456B2/en not_active Ceased
-
2000
- 2000-03-21 HK HK00101709A patent/HK1022694A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2402199A (en) | 1999-11-04 |
| NZ335388A (en) | 2000-03-27 |
| DE69901006D1 (de) | 2002-04-18 |
| FR2777886B1 (fr) | 2002-05-31 |
| CN1211362C (zh) | 2005-07-20 |
| FR2777886A1 (fr) | 1999-10-29 |
| AU744456B2 (en) | 2002-02-21 |
| JPH11349586A (ja) | 1999-12-21 |
| EP0955299B1 (fr) | 2002-03-13 |
| ES2174579T3 (es) | 2002-11-01 |
| NO991957L (no) | 1999-10-28 |
| CA2270086A1 (fr) | 1999-10-27 |
| HK1022694A1 (en) | 2000-08-18 |
| JP3957424B2 (ja) | 2007-08-15 |
| PT955299E (pt) | 2002-07-31 |
| CN1235156A (zh) | 1999-11-17 |
| ATE214387T1 (de) | 2002-03-15 |
| EP0955299A1 (fr) | 1999-11-10 |
| DE69901006T2 (de) | 2002-11-07 |
| NO319101B1 (no) | 2005-06-20 |
| HUP9901403A1 (hu) | 2000-06-28 |
| BR9901298A (pt) | 2000-05-02 |
| CA2270086C (fr) | 2005-04-05 |
| US6048875A (en) | 2000-04-11 |
| DK0955299T3 (da) | 2002-06-24 |
| NO991957D0 (no) | 1999-04-23 |
| HU9901403D0 (en) | 1999-06-28 |
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