ZA9711253B - N-benzylpiperazine compounds, process for preparing them and pharmaceutical compositions containing them. - Google Patents

N-benzylpiperazine compounds, process for preparing them and pharmaceutical compositions containing them.

Info

Publication number: ZA9711253B
Authority: ZA; South Africa
Prior art keywords: alkyl; optionally substituted; alkoxy; halo; phenyl
Prior art date: 1996-12-16

Application number

ZA9711253A

Other languages

English (en)

Inventor

Michel Wierzbicki

Marie-Francoise Boussard

Serge Labidalle

Daniel Guyot

Yves Rolland

Jean-Paul Tillement

Bernard Testa

Aime Crevat

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-16

Filing date

1997-12-15

Publication date

1998-06-23

1997-12-15 Application filed by Adir filed Critical Adir

1998-06-23 Publication of ZA9711253B publication Critical patent/ZA9711253B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrane Compounds (AREA)
Pyridine Compounds (AREA)

ZA9711253A 1996-12-16 1997-12-15 N-benzylpiperazine compounds, process for preparing them and pharmaceutical compositions containing them. ZA9711253B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9615415A FR2757164B1 (fr)	1996-12-16	1996-12-16	Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA9711253B true ZA9711253B (en)	1998-06-23

Family

ID=9498696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9711253A ZA9711253B (en)	1996-12-16	1997-12-15	N-benzylpiperazine compounds, process for preparing them and pharmaceutical compositions containing them.

Country Status (19)

Country	Link
US (1)	US5849745A (hu)
EP (1)	EP0847999B1 (hu)
JP (1)	JPH10175967A (hu)
CN (1)	CN1192436A (hu)
AT (1)	ATE199902T1 (hu)
AU (1)	AU720803B2 (hu)
BR (1)	BR9706360A (hu)
CA (1)	CA2225780C (hu)
DE (1)	DE69704329T2 (hu)
DK (1)	DK0847999T3 (hu)
ES (1)	ES2157541T3 (hu)
FR (1)	FR2757164B1 (hu)
GR (1)	GR3035855T3 (hu)
HU (1)	HUP9702481A3 (hu)
NO (1)	NO975903L (hu)
NZ (1)	NZ329394A (hu)
PL (1)	PL323767A1 (hu)
PT (1)	PT847999E (hu)
ZA (1)	ZA9711253B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2439634A1 (en) *	2001-03-01	2002-09-12	Technological Resources Pty Limited	Benzene-1 2-diol mannich bases ligands polymers and method of selective metal ions removal
FR2827284B1 (fr) *	2001-07-16	2003-10-31	Servier Lab	Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN102993122B (zh) *	2012-12-24	2015-03-04	武汉武药制药有限公司	盐酸曲美他嗪的合成新路线
CN117100751A (zh)	2017-06-20	2023-11-24	安布里亚制药公司	用于提高心脏代谢效率的组合物和方法
US11780811B2 (en)	2020-06-30	2023-10-10	Imbria Pharmaceuticals, Inc.	Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en)	2020-06-30	2022-12-20	Imbria Pharmaceuticals, Inc.	Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en)	2021-05-03	2024-01-30	Imbria Pharmaceuticals, Inc.	Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3262852A (en) *		1966-07-26		Vasodilator and anti-anginose com- pounds containing methoxy benzyl piperazines and method of using the same
US2927924A (en) *	1958-04-03	1960-03-08	Lilly Co Eli	Novel phenethyl-substituted piperazines
FR805M (hu) *	1960-06-30	1961-09-01
FR1302958A (fr) *	1961-03-21	1962-09-07	Science Union & Cie	Préparations des dérivés trialcoxylés de la benzyl-1 pipérazine
FR1303080A (fr) *	1961-07-25	1962-09-07	Science Union Et Compagnie Soc	Pipérazines disubstituées
CA1326451C (en) *	1988-01-26	1994-01-25	Nippon Chemiphar Co., Ltd.	Therapeutic agent for liver disease and piperazine derivatives
FR2681324B1 (fr) *	1991-09-18	1993-10-29	Adir Cie	Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2703048B1 (fr) *	1993-03-24	1996-01-05	Adir	Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.

1996
- 1996-12-16 FR FR9615415A patent/FR2757164B1/fr not_active Expired - Fee Related
1997
- 1997-12-04 ES ES97402934T patent/ES2157541T3/es not_active Expired - Lifetime
- 1997-12-04 DK DK97402934T patent/DK0847999T3/da active
- 1997-12-04 DE DE69704329T patent/DE69704329T2/de not_active Expired - Fee Related
- 1997-12-04 EP EP97402934A patent/EP0847999B1/fr not_active Expired - Lifetime
- 1997-12-04 PT PT97402934T patent/PT847999E/pt unknown
- 1997-12-04 AT AT97402934T patent/ATE199902T1/de not_active IP Right Cessation
- 1997-12-15 US US08/990,611 patent/US5849745A/en not_active Expired - Fee Related
- 1997-12-15 JP JP9344823A patent/JPH10175967A/ja active Pending
- 1997-12-15 ZA ZA9711253A patent/ZA9711253B/xx unknown
- 1997-12-15 PL PL97323767A patent/PL323767A1/xx unknown
- 1997-12-15 NZ NZ329394A patent/NZ329394A/xx unknown
- 1997-12-16 CA CA002225780A patent/CA2225780C/fr not_active Expired - Fee Related
- 1997-12-16 CN CN97107273A patent/CN1192436A/zh active Pending
- 1997-12-16 NO NO975903A patent/NO975903L/no not_active Application Discontinuation
- 1997-12-16 HU HU9702481A patent/HUP9702481A3/hu unknown
- 1997-12-16 AU AU48422/97A patent/AU720803B2/en not_active Ceased
- 1997-12-16 BR BR9706360A patent/BR9706360A/pt not_active Application Discontinuation
2001
- 2001-05-11 GR GR20010400707T patent/GR3035855T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP9702481A3 (en)	1999-03-01
CA2225780C (fr)	2002-11-19
DE69704329D1 (de)	2001-04-26
FR2757164B1 (fr)	1999-01-22
NO975903D0 (no)	1997-12-16
DK0847999T3 (da)	2001-04-30
FR2757164A1 (fr)	1998-06-19
CN1192436A (zh)	1998-09-09
US5849745A (en)	1998-12-15
JPH10175967A (ja)	1998-06-30
NO975903L (no)	1998-06-17
AU720803B2 (en)	2000-06-15
PL323767A1 (en)	1998-06-22
NZ329394A (en)	1998-10-28
ES2157541T3 (es)	2001-08-16
CA2225780A1 (fr)	1998-06-16
ATE199902T1 (de)	2001-04-15
AU4842297A (en)	1998-06-18
HUP9702481A2 (hu)	1998-07-28
DE69704329T2 (de)	2001-09-20
GR3035855T3 (en)	2001-08-31
PT847999E (pt)	2001-08-30
HU9702481D0 (en)	1998-03-02
EP0847999B1 (fr)	2001-03-21
EP0847999A1 (fr)	1998-06-17
BR9706360A (pt)	1999-06-01

Publication	Publication Date	Title
AU4017893A (en)	1993-12-16	New 1,4-disubstituted piperazine, a process for their preparation and pharmaceutical compositions containing them
IL114894A (en)	2003-04-10	Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
CZ103595A3 (en)	1995-12-13	Derivative of 3-indolylpiperidine, process of its preparation, its use for preparing a pharmaceutical preparation and and the pharmaceutical composition containing thereof
MY131193A (en)	2007-07-31	7-(2-aminoethyl)-benzothiazolones
ZA9711253B (en)	1998-06-23	N-benzylpiperazine compounds, process for preparing them and pharmaceutical compositions containing them.
IL96390A0 (en)	1991-08-16	Pharmaceutical compositions comprising n-alkylpiperazine-alkanamide derivatives for preventing or limiting reperfusion damage
ATE199083T1 (de)	2001-02-15	Terphenylverbindungen und sie enthaltende arzneimittel
MY135774A (en)	2008-06-30	Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them.
HU9503973D0 (en)	1996-03-28	Use of coumarins and carbostyrils as pla2-inhibitors, new coumarins and carbostyrils, process for preparing the same and medicaments
DE59304311D1 (de)	1996-11-28	N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika
ZA921341B (en)	1993-08-24	4-((2-benzothiazolyl)methylamino)-a-(3,4-difluorophenoxy) methyl)-1-piperidineethanol.
HK113597A (en)	1997-08-29	Nitrogen containing bicyclic derivatives method for their preparation and pharmaceutical compositions containing them
MY120617A (en)	2005-11-30	Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives.
AU625238B2 (en)	1992-07-02	Anti-psychotic piperidylbenzimidazole compounds
BG104424A (en)	2001-01-31	Pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl) methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
HK1027348A1 (en)	2001-01-12	New 1,2-dithiolane compounds, a process for their preparation and pharmaceutical compositions containing them
AU4012393A (en)	1993-12-16	New diacylglycerol nicotinates, process for their preparation and pharmaceutical compositions which contain them
IL115085A (en)	1999-06-20	Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
CA2314541A1 (fr)	2001-01-16	Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
ZA997735B (en)	2000-06-19	Spiro imidazoline compounds, a process for their preparation and pharmaceutical compositions containing them.
AU8716391A (en)	1992-05-26	Tri(lower alkoxy)benzene derivative
DK0816359T3 (da)	2005-03-14	4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse