[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ZA907338B - Thienylcarboxylates of amino alcohols - Google Patents

Thienylcarboxylates of amino alcohols

Info

Publication number
ZA907338B
ZA907338B ZA907338A ZA907338A ZA907338B ZA 907338 B ZA907338 B ZA 907338B ZA 907338 A ZA907338 A ZA 907338A ZA 907338 A ZA907338 A ZA 907338A ZA 907338 B ZA907338 B ZA 907338B
Authority
ZA
South Africa
Prior art keywords
thienylcarboxylates
amino alcohols
drugs
manufactured
formula
Prior art date
Application number
ZA907338A
Inventor
Rolf Banholzer
Rudolf Bauer
Richard Reichl
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6389619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA907338(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA907338B publication Critical patent/ZA907338B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Disintegrating Or Milling (AREA)

Abstract

The new compounds of formula (I) (where A, R1, Ra and R2 are defined in the description) can be manufactured by processes known per se and used as the active ingredients of drugs.
ZA907338A 1989-09-16 1990-09-14 Thienylcarboxylates of amino alcohols ZA907338B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931041A DE3931041C2 (en) 1989-09-16 1989-09-16 Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ZA907338B true ZA907338B (en) 1992-08-26

Family

ID=6389619

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA907338A ZA907338B (en) 1989-09-16 1990-09-14 Thienylcarboxylates of amino alcohols

Country Status (33)

Country Link
US (1) USRE39820E1 (en)
EP (1) EP0418716B1 (en)
JP (1) JPH0730074B2 (en)
KR (1) KR0168432B1 (en)
AT (1) ATE103914T1 (en)
AU (1) AU642913B2 (en)
BG (1) BG61295B2 (en)
CA (1) CA2066248C (en)
CZ (1) CZ284589B6 (en)
DD (1) DD297647A5 (en)
DE (3) DE3931041C2 (en)
DK (1) DK0418716T3 (en)
ES (1) ES2052125T3 (en)
FI (1) FI114395B (en)
HR (1) HRP940723B1 (en)
HU (2) HU208823B (en)
IE (1) IE65528B1 (en)
IL (1) IL95691A (en)
LU (1) LU90949I2 (en)
MX (1) MX9203150A (en)
NL (1) NL300084I2 (en)
NO (2) NO301478B1 (en)
NZ (1) NZ235306A (en)
PH (1) PH31617A (en)
PL (1) PL168468B1 (en)
PT (1) PT95312B (en)
RU (1) RU2073677C1 (en)
SI (1) SI9011744B (en)
SK (1) SK452390A3 (en)
UA (1) UA41272C2 (en)
WO (1) WO1991004252A1 (en)
YU (1) YU47800B (en)
ZA (1) ZA907338B (en)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (en) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
DE4108393A1 (en) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg NEW ESTERS BI-AND TRICYCLIC AMINO ALCOHOLS, THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE19921693A1 (en) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
SK287576B6 (en) 2000-08-05 2011-03-04 Glaxo Group Limited 6Alpha,9alpha-difluoro-17alpha-[(2-furanylcarboxyl)oxy]-11beta- hydroxy-16alpha-methyl-3-oxo-androst-1,4-diene-17beta-carbothioic acid S-fluoromethyl ester as an anti-inflammatory agent, method for the production, farmaceutical composition containing thereof, the use thereof and intermediates
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
CA2395653C (en) 2000-10-12 2006-05-09 Boehringer Ingelheim Pharma Kg New inhalable powder containing tiotropium
BR0114584A (en) * 2000-10-12 2003-08-26 Boehringer Ingelheim Pharma Crystalline monohydrate, processes for its preparation and its application for the preparation of a medicament
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE50113037D1 (en) * 2000-10-31 2007-10-31 Boehringer Ingelheim Pharma INHALATIVE SOLUTION FORMULATION WITH A TIOTROPIUM SALT
DE10064816A1 (en) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Production of tiotropium bromide useful as an anticholinergic comprises oxidation of di-(2-thienyl)-glycolic acid tropenol ester and subsequent quaternisation
EP1353919B1 (en) 2000-12-28 2006-07-26 Almirall Prodesfarma AG Novel quinuclidine derivatives and medicinal compositions containing the same
US6506900B1 (en) 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
IL158222A0 (en) 2001-04-30 2004-05-12 Glaxo Group Ltd Anti-inflammatory 17. beta-carbothioate ester derivatives of androstane with a cyclic ester group in position 17. alpha
DE10126924A1 (en) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalation capsule contains powdered mixture of tiotropium and auxiliary, for treating asthma or chronic obstructive pulmonary disease, having capsule material of low moisture content to improve stability
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
KR100971616B1 (en) * 2001-06-22 2010-07-22 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 Crystalline anticholinergic method for its production and pharmaceutical composition comprising the same
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
DE10141377A1 (en) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Scattering process for the production of powder formulations
CA2464223C (en) 2001-10-26 2009-05-26 Pharmacia & Upjohn Company Quarternary ammonium compounds and their use as antimuscarinic agents
DE10200943A1 (en) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Process for the preparation of scopine esters
DE10203749A1 (en) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma New anticholinergics, process for their preparation and their use as medicines
US6696462B2 (en) 2002-01-31 2004-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
WO2003068233A1 (en) * 2002-02-11 2003-08-21 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
GB0203193D0 (en) * 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
DE10212264A1 (en) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214264A1 (en) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA suspension formulations of an anhydrate
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
DE10216036A1 (en) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosol formulation for inhalation containing a tiotropium salt
DE10224091A1 (en) * 2002-05-31 2003-12-11 Boehringer Ingelheim Pharma Technical process for the production of tropenol
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
CA2513188A1 (en) * 2003-01-16 2004-08-05 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
JP4616264B2 (en) 2003-05-28 2011-01-19 セラヴァンス， インコーポレーテッド Azabicycloalkane compounds as muscarinic receptor antagonists
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
EA012369B1 (en) 2003-11-03 2009-10-30 Бёрингер Ингельхайм Интернациональ Гмбх Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
AU2004285683C1 (en) * 2003-11-03 2011-09-08 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
RS20060291A (en) * 2003-11-03 2008-06-05 Boehringer Ingelheim International Gmbh., Novel crystalline anhydride with anticholinergic effect
SE0303570L (en) 2003-12-03 2005-06-04 Microdrug Ag Moisture-sensitive medical product
WO2006025324A1 (en) * 2004-08-30 2006-03-09 Ono Pharmaceutical Co., Ltd. Tropan compound
PL1881980T3 (en) 2005-05-02 2013-01-31 Boehringer Ingelheim Int Novel crystalline forms of tiotropium bromide
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
DE102005035112A1 (en) 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg A new process for the preparation of tiotropium salts using N-methylscopinium salts soluble in organic solvents
CA2618089A1 (en) 2005-08-08 2007-02-15 Argenta Discovery Ltd. Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
TWI389692B (en) 2005-10-10 2013-03-21 Boehringer Ingelheim Int Aerosol formulations for the inhalation of beta-agonists
DE102005059602A1 (en) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Micronization process
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
WO2007075858A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Novel forms of tiotropium bromide and processes for preparation thereof
NZ570162A (en) * 2006-01-04 2011-09-30 Boehringer Ingelheim Int Use of tiotropium salts in the treatment of moderate persistent asthma which has the serverity of GINA step 3
ES2298049B1 (en) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. PROCEDURE FOR MANUFACTURING BROMIDE OF 3 (R) - (2-HIDROXI-2,2-DITIEN-2-ILACETOXI) -1- (3-PHENOXIPROPIL) -1-AZONIABICICLO (2.2.2) OCTANO.
CA2659539A1 (en) 2006-08-01 2008-02-07 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (en) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stable powder formulation containing a new antichinolinergic agent
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
CA2710523C (en) * 2008-01-10 2014-11-18 Generics [Uk] Limited Process for the preparation of scopine esters
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP4166107A1 (en) 2008-05-09 2023-04-19 Nuvaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
JP5873013B2 (en) * 2009-05-29 2016-03-01 パール セラピューティクス，インコーポレイテッド Compositions, methods and systems for respiratory delivery of two or more active agents
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
TR200907237A2 (en) 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Tiotropium dry powder combination
TR200907236A2 (en) 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Transport of Tiotropium dry powder formulation in blister pack.
CN112089394A (en) 2009-10-27 2020-12-18 努瓦拉公司 Delivery device with coolable energy emitting assembly
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
TR201000681A2 (en) * 2010-01-29 2011-08-22 B�Lg�� Mahmut Dry powder formulations inhaled.
WO2011093810A2 (en) 2010-01-28 2011-08-04 Bilgic Mahmut Dry powder pharmaceutical composition comprising tiotropium and mometasone
TR200909793A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Combination of dry powder containing a combination of tiotropium, mometasone and a chromoglycic acid derivative.
WO2011093809A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and ciclesonide
TR200909790A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Combination of dry powder containing a combination of tiotropium, formoterol and a chromoglycic acid derivative.
TR201000679A2 (en) * 2010-01-29 2011-08-22 B�Lg�� Mahmut Dry powder formulations containing a pharmaceutical combination.
TR200909789A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Dry powder combination containing tiotropium, budesonide and a chromoglycic acid derivative combination
WO2011093812A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Pharmaceutical formulation comprising tiotropium and budesonide in dry powder form
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
TR200909792A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Dry powder combination containing tiotropium, corticosteroid and a combination of chromoglycic acid derivative
TR200909788A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Dry powder formulation suitable for inhalation with tiotropium
EP2528600B1 (en) 2010-01-28 2016-06-29 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and fluticasone
TR201000733A2 (en) 2010-02-02 2011-08-22 Bi̇lgi̇ç Mahmut Pharmaceutical compositions comprising fluticasone, tiotropium and sodium chromoglycate.
TR201002520A2 (en) 2010-04-01 2010-05-21 Bi̇lgi̇ç Mahmut Tiotropium bromide manufacturing method.
US8957209B2 (en) 2010-04-01 2015-02-17 Mahmut Bilgic Methods for the synthesis of tiotropium bromide
TR201005222A2 (en) 2010-04-01 2011-10-21 Bi̇lgi̇ç Mahmut Tiotropium bromide synthesis method
TR201005221A2 (en) 2010-04-01 2012-01-23 Bi̇lgi̇ç Mahmut Improved synthesis method.
TR201007108A2 (en) 2010-08-25 2012-03-21 B�Lg�� Mahmut New tiotropium bromide crystal and production method.
TR201101897A2 (en) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Crystal material containing tiotropium bromide
TR201111589A2 (en) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropium bromide anhydrous crystal form.
TR201102068A2 (en) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Crystalline substances containing tiotropium bromide
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
ITRM20110508A1 (en) * 2011-09-27 2013-03-28 Lusochimica Spa PROCESS FOR THE PREPARATION OF SCOPINA'S ESTERS.
US8680297B2 (en) 2011-10-06 2014-03-25 Drug Process Licensing Assoc., LLC Manufacturing process for tiotropium bromide
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PL2607351T3 (en) * 2011-12-22 2017-08-31 Cerbios-Pharma S.A. Continuous process for the alkylation of cyclic tertiary amines
WO2013109213A2 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Pharmaceutical formulations comprising tiotropium
CZ201241A3 (en) 2012-01-20 2013-07-31 Zentiva, K.S. Novel polymorphous forms of thiotropium iodide and process for preparing thereof
PT106142B (en) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
US20150165038A1 (en) 2012-02-10 2015-06-18 Arven llac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and sorbitol
EP2819669B1 (en) 2012-02-28 2021-04-21 Boehringer Ingelheim International GmbH New tiotropium formula containing propellant
CZ304808B6 (en) * 2012-03-16 2014-11-05 Zentiva, K.S. Process for preparing scopine ester of di-(2- thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide and a new form thereof
CZ305012B6 (en) * 2012-03-30 2015-03-25 Zentiva, K.S. Process for preparing scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide
WO2014007771A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising muscarinic receptor antagonist
US20150174064A1 (en) 2012-07-05 2015-06-25 Arven IIac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and glucose anhydrous
EP2705838A1 (en) 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
HUE032455T2 (en) 2012-11-05 2017-09-28 Zentiva Ks Stabilization of tiotropium solvates
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US20140275517A1 (en) 2013-03-15 2014-09-18 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
KR20150135328A (en) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 Tiotropium dry powders
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
ES2826562T3 (en) 2015-05-18 2021-05-18 Glenmark Specialty Sa Tiotropium Inhalation Solution by Nebulizer
US9987260B2 (en) 2015-05-18 2018-06-05 Glenmark Specialty S.A. Tiotropium inhalation solution for nebulization
US10653683B2 (en) 2015-05-18 2020-05-19 Glenmark Specialty S.A. Tiotropium inhalation solution for nebulization
KR101748796B1 (en) 2015-09-30 2017-06-19 한미약품 주식회사 Inhalation capsule with enhanced delivery rate of active ingredients
BR112018008083A2 (en) 2015-10-23 2018-10-23 Arven Ilac Sanayi Ve Ticaret As tiotropium bromide inhalable blister
WO2017068119A1 (en) 2015-10-23 2017-04-27 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
CN106467535A (en) * 2016-08-28 2017-03-01 杭州百诚医药科技股份有限公司 One kind prepares the purifying process of 2,2 pairs of (2 thienyl) glycolic Rhizoma Scopoliae Japonicae esters
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
EP3525773A1 (en) 2016-10-14 2019-08-21 Glenmark Specialty S.A. Nebulizable compositions of tiotropium and formoterol
KR102476726B1 (en) 2016-11-16 2022-12-12 글렌마크 스페셜티 에스. 에이. Nebulized Tiotropium
WO2020141472A1 (en) 2019-01-03 2020-07-09 Glenmark Specialty S.A. Nebulization composition comprising tiotropium and indacaterol
SMT202400370T1 (en) 2021-07-09 2024-11-15 Astrazeneca Pharmaceuticals Lp Compositions, methods and systems for aerosol drug delivery
CN114213408B (en) * 2021-12-15 2023-03-31 台州仙琚药业有限公司 Preparation method of tiotropium bromide
EP4452230A1 (en) 2021-12-20 2024-10-30 Astrazeneca AB Compositions, methods and systems for aerosol drug delivery

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB845056A (en) 1957-07-05 1960-08-17 Egyt Gyogyszervegyeszeti Gyar Improvements in or relating to tropane derivatives
DE1166787B (en) * 1960-07-09 1964-04-02 Boehringer & Soehne Gmbh Process for the production of new garnetanol (3ª ‰) esters and their hydrohalides
GB955535A (en) * 1962-10-22 1964-04-15 Boehringer & Soehne Gmbh New n-substituted norgranatanol-(3ª‰)-esters
DE2046659A1 (en) 1970-01-28 1972-03-23
US3808263A (en) * 1970-05-12 1974-04-30 Tanabe Seiyaku Co 6,6-dimethyl-9-alkyl-9-azabicyclo(3.3.1)nonan-3-ols
US3673195A (en) * 1970-05-25 1972-06-27 Tanabe Seiyaku Co Derivatives of 6,6,9-tri-lower alkyl-9-azabicyclo(3.3.1) nonan-3{60 -or 3{62 -ol
US4353922A (en) * 1981-03-13 1982-10-12 Syntex (U.S.A.) Inc. Anticholinergic bronchodilators
DE3546218A1 (en) 1985-12-27 1987-07-02 Madaus & Co Dr AZONIA SPIRONORTROPANOLESTER, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT
DE3931041C2 (en) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them

Also Published As

Publication number Publication date
NL300084I2 (en) 2002-08-01
HUT60740A (en) 1992-10-28
DK0418716T3 (en) 1994-05-02
HRP940723B1 (en) 1999-10-31
PH31617A (en) 1999-01-12
NZ235306A (en) 1997-06-24
EP0418716A1 (en) 1991-03-27
LU90949I2 (en) 2002-10-30
PT95312B (en) 1997-06-30
RU2073677C1 (en) 1997-02-20
IE903342A1 (en) 1991-04-10
NL300084I1 (en) 2002-05-01
HU208823B (en) 1994-01-28
IL95691A0 (en) 1991-06-30
KR910006272A (en) 1991-04-29
JPH0730074B2 (en) 1995-04-05
JPH05502438A (en) 1993-04-28
DE59005250D1 (en) 1994-05-11
MX9203150A (en) 1992-07-01
HU9200857D0 (en) 1992-05-28
DE3931041A1 (en) 1991-03-28
SI9011744A (en) 1997-10-31
SK279453B6 (en) 1998-11-04
PL168468B1 (en) 1996-02-29
PL286900A1 (en) 1991-12-02
IE65528B1 (en) 1995-11-01
USRE39820E1 (en) 2007-09-04
IL95691A (en) 1996-07-23
DE10299026I1 (en) 2002-11-07
NO921002D0 (en) 1992-03-13
DE10299026I2 (en) 2004-07-01
PT95312A (en) 1991-05-22
FI921087A0 (en) 1992-03-13
SI9011744B (en) 1999-12-31
KR0168432B1 (en) 1999-01-15
NO921002L (en) 1992-03-13
YU174490A (en) 1993-10-20
WO1991004252A1 (en) 1991-04-04
AU6431890A (en) 1991-04-18
CZ284589B6 (en) 1999-01-13
CZ452390A3 (en) 1998-11-11
CA2066248C (en) 1998-08-04
YU47800B (en) 1996-01-09
NO301478B1 (en) 1997-11-03
NO2002009I2 (en) 2004-10-11
BG61295B2 (en) 1997-04-30
HU210612A9 (en) 1995-05-29
ES2052125T3 (en) 1994-07-01
UA41272C2 (en) 2001-09-17
CA2066248A1 (en) 1991-03-17
EP0418716B1 (en) 1994-04-06
FI114395B (en) 2004-10-15
SK452390A3 (en) 1998-11-04
DE3931041C2 (en) 2000-04-06
DD297647A5 (en) 1992-01-16
AU642913B2 (en) 1993-11-04
HRP940723A2 (en) 1997-06-30
ATE103914T1 (en) 1994-04-15

Similar Documents

Publication Publication Date Title
ZA907338B (en) Thienylcarboxylates of amino alcohols
EG18729A (en) Compound of n- amino - 1,2,4-triazinones used as insecticide.
GR852997B (en)
PL285248A1 (en) Method of obtaining novel aminophenol derivatives
EG18379A (en) Novel pharmacological compounds
IT1228288B (en) COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
EP0411733A3 (en) 11-beta-aryle-gona-4,9-dien-3-ones
PT80752A (en) Process for preparing solid medicament formulations containing dihydropyridines
HUT47793A (en) Herbicide compositions containing 2,6-substituted-pyridine-carboxylic acid derivatives as active components and process for producing the active components
HUT44011A (en) Herbicide compositions containing n-substituted-3,4,5,6-tetrahydro-phtalimide derivatives as active components and process for producing the active components
HUT50787A (en) Process for producing pharmaceutical compositions comprising 4-aryl-4-piperidine-, pyrrolidine- or hexahydroazepincarbinol derivatives or heterocyclic analogs thereof as active ingredient and process for producing the new compounds
EP0401262A4 (en) 24r-scymnol, and preparation and use thereof
NZ219284A (en) Fluoboric acid salt of n-tridecyl-2,6-dimethylmorpholine and pesticidal compositions
EP0246861A3 (en) Pharmaceutical composition based on crotoxine, process for preparing the active component and the pharmaceutical composition
PT87563A (en) PROCESS FOR THE PREPARATION OF VINYLCEPHALOSPORINS USEFUL AS MEDICAMENTS
HUT44132A (en) Herbicide compositions containing pyrazolo-(-3,4-b-)-pyridine derivatives as active components and process for producing the active components
ES2044144T3 (en) NEW PROCEDURE FOR THE PRODUCTION OF 4,6-DIMETIL-7-HIDROXINONAN-3-ONA.
AU8082687A (en) 2,6-diamino-3-halobenzylpyridines and processes for their manufacture as well as their use in pharmaceuticals
ES8606248A1 (en) Process for the preparation of optically active glycine derivatives.
ES2001042A6 (en) Process for the preparation of 5,6-dialkoxyanthranilic acids.
EP0264017A3 (en) Pharmaceutical compositions having healing activity
AU645041B2 (en) N-(3&#39;,4&#39;-dimethoxycinnamoyl)anthranilic acid
AU592708C (en) Injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-(4-{p-(bis(2- chloroethyl)amino)phenyl}-butanoyloxy)acetate as an active ingredient
AU1971088A (en) Injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-(4-{p-(bis(2- chloroethyl)amino)phenyl}-butanoyloxy)acetate as an active ingredient