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ZA898784B - Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof - Google Patents

Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof

Info

Publication number
ZA898784B
ZA898784B ZA898784A ZA898784A ZA898784B ZA 898784 B ZA898784 B ZA 898784B ZA 898784 A ZA898784 A ZA 898784A ZA 898784 A ZA898784 A ZA 898784A ZA 898784 B ZA898784 B ZA 898784B
Authority
ZA
South Africa
Prior art keywords
dipeptides
renin
preparation
urea derivatives
agents containing
Prior art date
Application number
ZA898784A
Inventor
Wolfgang Rueger
Rueger Wolfgang
Hansjoerg Urbach
Urbach Hansjoerg
Dieter Ruppert
Ruppert Dieter
Bernward Schoelkens
Schoelkens Bernward
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA898784B publication Critical patent/ZA898784B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA898784A 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof ZA898784B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839126A DE3839126A1 (en) 1988-11-19 1988-11-19 RENIN-INHIBITING UREA DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE

Publications (1)

Publication Number Publication Date
ZA898784B true ZA898784B (en) 1990-08-29

Family

ID=6367476

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898784A ZA898784B (en) 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof

Country Status (12)

Country Link
EP (1) EP0370382A3 (en)
JP (1) JPH02180898A (en)
KR (1) KR900007868A (en)
AU (1) AU616071B2 (en)
DE (1) DE3839126A1 (en)
DK (1) DK579089A (en)
FI (1) FI895462A0 (en)
HU (1) HU203771B (en)
IL (1) IL92348A0 (en)
NO (1) NO894569L (en)
PT (1) PT92330A (en)
ZA (1) ZA898784B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3841520A1 (en) * 1988-12-09 1990-06-13 Hoechst Ag ENZYME-INFRINGING DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, METHODS CONTAINING THEM AND THEIR USE
DE4014421A1 (en) * 1990-05-05 1991-11-07 Merck Patent Gmbh AMINOSAEUREDERIVATE
WO2014100719A2 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016505000A (en) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド PRMT5 inhibitors and uses thereof
US9611257B2 (en) 2012-12-21 2017-04-04 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2016022605A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
GB8707412D0 (en) * 1987-03-27 1987-04-29 Fujisawa Pharmaceutical Co Peptide compounds
DE3841520A1 (en) * 1988-12-09 1990-06-13 Hoechst Ag ENZYME-INFRINGING DERIVATIVES OF DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, METHODS CONTAINING THEM AND THEIR USE

Also Published As

Publication number Publication date
AU4479889A (en) 1990-08-09
PT92330A (en) 1990-05-31
JPH02180898A (en) 1990-07-13
IL92348A0 (en) 1990-07-26
DK579089A (en) 1990-05-20
NO894569L (en) 1990-05-21
HUT53122A (en) 1990-09-28
DK579089D0 (en) 1989-11-17
NO894569D0 (en) 1989-11-16
KR900007868A (en) 1990-06-02
EP0370382A2 (en) 1990-05-30
DE3839126A1 (en) 1990-05-23
EP0370382A3 (en) 1991-04-10
HU895948D0 (en) 1990-02-28
HU203771B (en) 1991-09-30
FI895462A0 (en) 1989-11-16
AU616071B2 (en) 1991-10-17

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