ZA856414B - Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use - Google Patents
Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical useInfo
- Publication number
- ZA856414B ZA856414B ZA856414A ZA856414A ZA856414B ZA 856414 B ZA856414 B ZA 856414B ZA 856414 A ZA856414 A ZA 856414A ZA 856414 A ZA856414 A ZA 856414A ZA 856414 B ZA856414 B ZA 856414B
- Authority
- ZA
- South Africa
- Prior art keywords
- butyrolactams
- preparation
- pharmacologically active
- medical use
- active compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- WGYGSZOQGYRGIP-MWDXBVQZSA-N (3r,4s,5s)-3-hydroxy-5-[(r)-hydroxy(phenyl)methyl]-1-methyl-4-phenylpyrrolidin-2-one Chemical compound C1([C@@H](O)[C@H]2N(C([C@H](O)[C@H]2C=2C=CC=CC=2)=O)C)=CC=CC=C1 WGYGSZOQGYRGIP-MWDXBVQZSA-N 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 241001292317 Clausena Species 0.000 abstract 1
- VRSSZILNAITUII-UHFFFAOYSA-N Clausenamide Natural products OC1C(=O)N(C)C=CC2=CC=CC=C2C1C1=CC=CC=C1 VRSSZILNAITUII-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- WGYGSZOQGYRGIP-UHFFFAOYSA-N neoclausenamide Natural products C=1C=CC=CC=1C1C(O)C(=O)N(C)C1C(O)C1=CC=CC=C1 WGYGSZOQGYRGIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Package Frames And Binding Bands (AREA)
- Joining Of Building Structures In Genera (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843431257 DE3431257A1 (de) | 1984-08-24 | 1984-08-24 | Neue (delta)-butyrolactame, pharmakologisch aktive zusammensetzungen derselben, verfahren zu ihrer herstellung und ihre medizinische verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA856414B true ZA856414B (en) | 1986-04-30 |
Family
ID=6243847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA856414A ZA856414B (en) | 1984-08-24 | 1985-08-23 | Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4879390A (es) |
| EP (1) | EP0172514B1 (es) |
| JP (1) | JPH0660159B2 (es) |
| KR (1) | KR860001787A (es) |
| AT (1) | ATE46504T1 (es) |
| AU (1) | AU571729B2 (es) |
| CA (1) | CA1262250A (es) |
| DE (2) | DE3431257A1 (es) |
| DK (1) | DK385285A (es) |
| ES (2) | ES8609241A1 (es) |
| FI (1) | FI853228A7 (es) |
| GR (1) | GR852050B (es) |
| HU (1) | HU195774B (es) |
| IL (1) | IL76157A (es) |
| PT (1) | PT81005B (es) |
| ZA (1) | ZA856414B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU579029B2 (en) * | 1985-10-18 | 1988-11-10 | Bayer Aktiengesellschaft | Process for the preparation of ` -butyrolactams |
| DE3616989A1 (de) * | 1986-05-21 | 1987-11-26 | Bayer Ag | Enantiomerenreine 4,5-disubstituierte (gamma)-butyrolactame, verfahren zu ihrer herstellung und ihre verwendung |
| DE3927370A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von clausenamid und neoclausenamid und deren derivate |
| DE3927367A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von dehydrocycloclausenamid und dessen derivate in der racemischen form und als optisch aktive (+) oder (-)-enantiomere |
| JP4585073B2 (ja) * | 2000-02-15 | 2010-11-24 | 丸善製薬株式会社 | 抗男性ホルモン剤、養毛化粧料、前立腺肥大抑制剤、外用剤及び飲食品 |
| EP1348696B1 (en) * | 2002-03-26 | 2012-02-01 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Use of optically active clausenamides for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same |
| US6787564B2 (en) * | 2002-03-26 | 2004-09-07 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use |
| CN1295215C (zh) * | 2002-12-31 | 2007-01-17 | 中国医学科学院药物研究所 | 黄皮酰胺的光学活性衍生物、其制法和其药物组合物与用途 |
| WO2016015333A1 (en) * | 2014-08-01 | 2016-02-04 | F.Hoffmann-La Roche Ag | 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI325174A7 (es) * | 1973-11-19 | 1975-05-20 | Sandoz Ag |
-
1984
- 1984-08-24 DE DE19843431257 patent/DE3431257A1/de not_active Withdrawn
-
1985
- 1985-08-12 EP EP85110087A patent/EP0172514B1/en not_active Expired
- 1985-08-12 DE DE8585110087T patent/DE3573113D1/de not_active Expired
- 1985-08-12 AT AT85110087T patent/ATE46504T1/de not_active IP Right Cessation
- 1985-08-21 IL IL76157A patent/IL76157A/xx unknown
- 1985-08-22 PT PT81005A patent/PT81005B/pt unknown
- 1985-08-22 CA CA000489253A patent/CA1262250A/en not_active Expired
- 1985-08-22 AU AU46571/85A patent/AU571729B2/en not_active Ceased
- 1985-08-22 FI FI853228A patent/FI853228A7/fi not_active Application Discontinuation
- 1985-08-22 JP JP60183161A patent/JPH0660159B2/ja not_active Expired - Lifetime
- 1985-08-23 ZA ZA856414A patent/ZA856414B/xx unknown
- 1985-08-23 DK DK385285A patent/DK385285A/da not_active Application Discontinuation
- 1985-08-23 GR GR852050A patent/GR852050B/el unknown
- 1985-08-23 ES ES546381A patent/ES8609241A1/es not_active Expired
- 1985-08-23 KR KR1019850006078A patent/KR860001787A/ko not_active Abandoned
- 1985-08-23 HU HU853219A patent/HU195774B/hu not_active IP Right Cessation
-
1986
- 1986-04-16 ES ES554061A patent/ES8704457A1/es not_active Expired
-
1988
- 1988-04-27 US US07/186,540 patent/US4879390A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK385285D0 (da) | 1985-08-23 |
| ES8609241A1 (es) | 1986-07-16 |
| ES546381A0 (es) | 1986-07-16 |
| JPS62181250A (ja) | 1987-08-08 |
| IL76157A0 (en) | 1985-12-31 |
| ES554061A0 (es) | 1987-04-01 |
| HUT38904A (en) | 1986-07-28 |
| FI853228A0 (fi) | 1985-08-22 |
| CA1262250A (en) | 1989-10-10 |
| GR852050B (es) | 1985-12-20 |
| DE3431257A1 (de) | 1986-03-06 |
| FI853228L (fi) | 1986-02-25 |
| DK385285A (da) | 1986-02-25 |
| IL76157A (en) | 1988-08-31 |
| ATE46504T1 (de) | 1989-10-15 |
| EP0172514B1 (en) | 1989-09-20 |
| AU571729B2 (en) | 1988-04-21 |
| KR860001787A (ko) | 1986-03-22 |
| JPH0660159B2 (ja) | 1994-08-10 |
| EP0172514A1 (en) | 1986-02-26 |
| AU4657185A (en) | 1986-02-27 |
| HU195774B (en) | 1988-07-28 |
| ES8704457A1 (es) | 1987-04-01 |
| PT81005B (en) | 1987-06-26 |
| DE3573113D1 (en) | 1989-10-26 |
| FI853228A7 (fi) | 1986-02-25 |
| PT81005A (en) | 1985-09-01 |
| US4879390A (en) | 1989-11-07 |
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