ZA200600761B - Oral delivery system comprising a biliquid foam - Google Patents

Oral delivery system comprising a biliquid foam Download PDF

Info

Publication number: ZA200600761B
Authority: ZA; South Africa
Prior art keywords: delivery system; drug delivery; oral drug; agent; weight
Prior art date: 2003-07-30

Application number

ZA200600761A

Other languages

English (en)

Inventor

Charman William

Dias Monica

Georgiou Michelle

Guffogg Philip

Porter Christopher

Pouton Colin

Steele Fraser

Wheeler Derek Alfred

Original Assignee

Drug Delivery Solutions Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-30

Filing date

2004-07-30

Publication date

2007-05-30

2004-07-30 Application filed by Drug Delivery Solutions Ltd filed Critical Drug Delivery Solutions Ltd

2007-05-30 Publication of ZA200600761B publication Critical patent/ZA200600761B/en

Links

239000006260 foam Substances 0.000 title claims description 18
229940079593 drug Drugs 0.000 claims description 36
239000003814 drug Substances 0.000 claims description 36
238000012377 drug delivery Methods 0.000 claims description 30
239000000203 mixture Substances 0.000 claims description 28
229940126701 oral medication Drugs 0.000 claims description 24
239000012071 phase Substances 0.000 claims description 20
239000004094 surface-active agent Substances 0.000 claims description 17
-1 fatty acid ester Chemical class 0.000 claims description 16
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
239000003921 oil Substances 0.000 claims description 13
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
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150000003839 salts Chemical class 0.000 claims description 7
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
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239000003795 chemical substances by application Substances 0.000 claims description 5
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DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical group C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
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235000019864 coconut oil Nutrition 0.000 description 3
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GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
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239000011780 sodium chloride Substances 0.000 description 1
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239000007787 solid Substances 0.000 description 1
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SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
229960004306 sulfadiazine Drugs 0.000 description 1
229960000654 sulfafurazole Drugs 0.000 description 1
QPPBRPIAZZHUNT-UHFFFAOYSA-N sulfamerazine Chemical compound CC1=CC=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 QPPBRPIAZZHUNT-UHFFFAOYSA-N 0.000 description 1
229960002597 sulfamerazine Drugs 0.000 description 1
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GECHUMIMRBOMGK-UHFFFAOYSA-N sulfapyridine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=CC=N1 GECHUMIMRBOMGK-UHFFFAOYSA-N 0.000 description 1
229960002211 sulfapyridine Drugs 0.000 description 1
NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
229960001940 sulfasalazine Drugs 0.000 description 1
229960003329 sulfinpyrazone Drugs 0.000 description 1
MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 description 1
229960000894 sulindac Drugs 0.000 description 1
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
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229960002573 sultiame Drugs 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
FQZYTYWMLGAPFJ-OQKDUQJOSA-N tamoxifen citrate Chemical compound [H+].[H+].[H+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 FQZYTYWMLGAPFJ-OQKDUQJOSA-N 0.000 description 1
229960003454 tamoxifen citrate Drugs 0.000 description 1
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BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
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229960002180 tetracycline Drugs 0.000 description 1
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235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
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WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
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WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 description 1
229960001023 tibolone Drugs 0.000 description 1
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229960004214 tioconazole Drugs 0.000 description 1
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OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
229960005371 tolbutamide Drugs 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
229960001288 triamterene Drugs 0.000 description 1
229960003386 triazolam Drugs 0.000 description 1
JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
MAYCICSNZYXLHB-UHFFFAOYSA-N tricaproin Chemical compound CCCCCC(=O)OCC(OC(=O)CCCCC)COC(=O)CCCCC MAYCICSNZYXLHB-UHFFFAOYSA-N 0.000 description 1
229960003904 triflupromazine Drugs 0.000 description 1
XSCGXQMFQXDFCW-UHFFFAOYSA-N triflupromazine Chemical compound C1=C(C(F)(F)F)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 XSCGXQMFQXDFCW-UHFFFAOYSA-N 0.000 description 1
229960001032 trihexyphenidyl Drugs 0.000 description 1
VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
229960001082 trimethoprim Drugs 0.000 description 1
229960002835 trimipramine maleate Drugs 0.000 description 1
YDGHCKHAXOUQOS-BTJKTKAUSA-N trimipramine maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.C1CC2=CC=CC=C2[NH+](CC(C[NH+](C)C)C)C2=CC=CC=C21 YDGHCKHAXOUQOS-BTJKTKAUSA-N 0.000 description 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
229940117972 triolein Drugs 0.000 description 1
229960004791 tropicamide Drugs 0.000 description 1
MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
229960000604 valproic acid Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
239000008170 walnut oil Substances 0.000 description 1
239000010497 wheat germ oil Substances 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
229960000820 zopiclone Drugs 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Dispersion Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)
Cosmetics (AREA)
Orthopedics, Nursing, And Contraception (AREA)

ZA200600761A 2003-07-30 2004-07-30 Oral delivery system comprising a biliquid foam ZA200600761B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0317869.6A GB0317869D0 (en)	2003-07-30	2003-07-30	Improved drug delivery system

Publications (1)

Publication Number	Publication Date
ZA200600761B true ZA200600761B (en)	2007-05-30

Family

ID=27799499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200600761A ZA200600761B (en)	2003-07-30	2004-07-30	Oral delivery system comprising a biliquid foam

Country Status (14)

Country	Link
US (1)	US20060228408A1 (ru)
EP (1)	EP1653923B1 (ru)
JP (1)	JP4953815B2 (ru)
CN (2)	CN101579311B (ru)
AT (1)	ATE465715T1 (ru)
AU (1)	AU2004261053B2 (ru)
CA (1)	CA2533833C (ru)
DE (1)	DE602004026879D1 (ru)
DK (1)	DK1653923T3 (ru)
ES (1)	ES2344898T3 (ru)
GB (1)	GB0317869D0 (ru)
RU (1)	RU2353350C2 (ru)
WO (1)	WO2005011628A2 (ru)
ZA (1)	ZA200600761B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0404403D0 (en)	2004-02-27	2004-03-31	Disperse Ltd	Dispersions
US10265265B2 (en)	2007-03-15	2019-04-23	Drug Delivery Solutions Limited	Topical composition
EP2008651A1 (en)	2007-06-26	2008-12-31	Drug Delivery Solutions Limited	A bioerodible patch
GB0712389D0 (en) *	2007-06-26	2007-08-01	Drug Delivery Solutions Ltd	A Pharmaceutical composition
CN101780037B (zh) *	2010-02-03	2011-11-16	南昌大学	双嘧达莫自乳化给药系统及其制备方法
GB201006218D0 (en)	2010-04-14	2010-06-02	Ayanda As	Composition
WO2012123515A1 (en) *	2011-03-14	2012-09-20	Drug Delivery Solutions Limited	An ophthalmic composition
EP3178470A1 (en) *	2011-04-11	2017-06-14	Vitux Group AS	Oral pharmaceutical dispersion compositions
EP3542788A1 (en)	2018-03-19	2019-09-25	MC2 Therapeutics Limited	Topical composition comprising calcipotriol and betamethasone dipropionate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4486333A (en) *	1981-04-10	1984-12-04	Felix Sebba	Preparation of biliquid foam compositions
US4999198A (en) *	1989-03-23	1991-03-12	The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations	Polyaphrons as a drug delivery system
US5840881A (en) *	1992-11-27	1998-11-24	Takeda Chemical Industries, Ltd.	Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
AU721918B2 (en) *	1996-03-08	2000-07-20	Disperse Limited	Dispersion comprising an oil-based biliquid foam and an aqueous gel
NL1003503C2 (nl) *	1996-07-04	1998-01-07	Negma Steba International Dev	Farmaceutische samenstelling voor orale toediening.
GB2326337A (en) *	1997-06-20	1998-12-23	Phares Pharma Holland	Homogeneous lipid compositions for drug delivery
ES2230276T3 (es) *	2000-02-22	2005-05-01	Color Access, Inc.	Composiciones cosmeticas acuosas gelificadas.
GB0214793D0 (en) *	2002-06-26	2002-08-07	Disperse Technologies Plc	Biliquid foam entrapment

2003
- 2003-07-30 GB GBGB0317869.6A patent/GB0317869D0/en not_active Ceased
2004
- 2004-07-30 DK DK04767956.8T patent/DK1653923T3/da active
- 2004-07-30 US US10/566,209 patent/US20060228408A1/en not_active Abandoned
- 2004-07-30 AT AT04767956T patent/ATE465715T1/de not_active IP Right Cessation
- 2004-07-30 DE DE602004026879T patent/DE602004026879D1/de not_active Expired - Lifetime
- 2004-07-30 AU AU2004261053A patent/AU2004261053B2/en not_active Ceased
- 2004-07-30 JP JP2006521672A patent/JP4953815B2/ja not_active Expired - Lifetime
- 2004-07-30 RU RU2006106173/15A patent/RU2353350C2/ru active
- 2004-07-30 EP EP04767956A patent/EP1653923B1/en not_active Expired - Lifetime
- 2004-07-30 CN CN2009101468709A patent/CN101579311B/zh not_active Expired - Fee Related
- 2004-07-30 CN CNA2004800223841A patent/CN1832727A/zh active Pending
- 2004-07-30 CA CA2533833A patent/CA2533833C/en not_active Expired - Lifetime
- 2004-07-30 ES ES04767956T patent/ES2344898T3/es not_active Expired - Lifetime
- 2004-07-30 ZA ZA200600761A patent/ZA200600761B/en unknown
- 2004-07-30 WO PCT/GB2004/003329 patent/WO2005011628A2/en active Search and Examination

Also Published As

Publication number	Publication date
US20060228408A1 (en)	2006-10-12
RU2006106173A (ru)	2007-09-10
CA2533833C (en)	2013-05-28
CA2533833A1 (en)	2005-02-10
GB0317869D0 (en)	2003-09-03
JP4953815B2 (ja)	2012-06-13
WO2005011628A2 (en)	2005-02-10
AU2004261053B2 (en)	2011-08-25
DK1653923T3 (da)	2010-08-09
AU2004261053A1 (en)	2005-02-10
CN101579311B (zh)	2013-11-27
JP2007500181A (ja)	2007-01-11
CN1832727A (zh)	2006-09-13
CN101579311A (zh)	2009-11-18
EP1653923A2 (en)	2006-05-10
ATE465715T1 (de)	2010-05-15
ES2344898T3 (es)	2010-09-09
RU2353350C2 (ru)	2009-04-27
EP1653923B1 (en)	2010-04-28
WO2005011628A3 (en)	2005-05-06
DE602004026879D1 (de)	2010-06-10

Publication	Publication Date	Title
US20230165878A1 (en)	2023-06-01	Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
EP0750495B1 (en)	2002-12-04	Use of a lipophilic surfactant in a pharmaceutical composition
JP2002537317A (ja)	2002-11-05	疎水性治療剤の改善された送達のための組成物および方法
EP2008651A1 (en)	2008-12-31	A bioerodible patch
US20100260835A1 (en)	2010-10-14	Pharmaceutical composition
AU2004261053B2 (en)	2011-08-25	Oral delivery system comprising a biliquid foam